Organization of the HIV-1 Virion
Scientists at the Dana-Farber Cancer Institute have identified a protein that blocks HIV replication in monkey cells. Humans have a similar protein, although it is not as effective at stopping HIV, say the researchers whose work is published in this week’s issue of Nature. The team, headed by Joseph Sodroski, M.D., is supported by the NIH’s National Institute of Allergy and Infectious Diseases (NIAID).
"Identification of this HIV-blocking factor opens new avenues for intervening in the early stage of HIV infection, before the virus can gain a toehold," says NIAID Director Anthony S. Fauci, M.D. "The discovery also gives us critical insights about viral uncoating, a little understood step in the viral lifecycle. Basic discoveries like this provide the scientific springboard to future improvements in therapies for HIV disease."
"Over the years," notes Dr. Sodroski, "we’ve learned quite a bit about how HIV enters cells. More recently, we’ve developed a picture of the late stages of the viral lifecycle, as it leaves the cell. However, the steps between virus entry and conversion of the viral RNA into DNA have been a black box." A key preparatory step is the removal, or uncoating, of the protective shell surrounding HIV’s genetic material. This coat, called the capsid, must be removed before HIV can insert its genetic material into the host cell’s DNA and begin to make copies of itself. (See http://www.niaid.nih.gov/newsroom/graphics/hiv1.jpg for a simplified diagram of HIV, including the capsid.)
Anne A. Oplinger | EurekAlert!
New eDNA technology used to quickly assess coral reefs
18.04.2019 | University of Hawaii at Manoa
New automated biological-sample analysis systems to accelerate disease detection
18.04.2019 | Polytechnique Montréal
A stellar flare 10 times more powerful than anything seen on our sun has burst from an ultracool star almost the same size as Jupiter
A localization phenomenon boosts the accuracy of solving quantum many-body problems with quantum computers which are otherwise challenging for conventional computers. This brings such digital quantum simulation within reach on quantum devices available today.
Quantum computers promise to solve certain computational problems exponentially faster than any classical machine. “A particularly promising application is the...
The technology could revolutionize how information travels through data centers and artificial intelligence networks
Engineers at the University of California, Berkeley have built a new photonic switch that can control the direction of light passing through optical fibers...
Physicists observe how electron-hole pairs drift apart at ultrafast speed, but still remain strongly bound.
Modern electronics relies on ultrafast charge motion on ever shorter length scales. Physicists from Regensburg and Gothenburg have now succeeded in resolving a...
Engineers create novel optical devices, including a moth eye-inspired omnidirectional microwave antenna
A team of engineers at Tufts University has developed a series of 3D printed metamaterials with unique microwave or optical properties that go beyond what is...
17.04.2019 | Event News
15.04.2019 | Event News
09.04.2019 | Event News
18.04.2019 | Life Sciences
18.04.2019 | Physics and Astronomy
18.04.2019 | Life Sciences