Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Sophisticated silencing strategies

25.02.2004



Since small RNA molecules were discovered just over ten years ago, it has become clear that these once overlooked bits of genetic material play a decidedly large role in controlling gene expression and thus regulating a diverse array of cellular processes. They typically accomplish these tasks by targeting specific nucleotide sequences to shut down gene expression, and scientists are now starting to apply related strategies to inactivate specific genes for research and therapeutic purposes (see related feature article by Richard Robinson at http://www.plosbiology.org/plosonline/?request=get-document&doi=10.1371/journal.pbio.0020028).

Yet much remains to be learned about the details of small-RNA-mediated silencing, and a study lead by James Carrington (Oregon State University) and Steve Jacobsen (UCLA) now demonstrates that plants have evolved multiple systems to produce distinct classes of small RNAs with specialized functions. These include genome maintenance, the regulation of specific endogenous target genes, and defense against viral and transposon sequences. These results shed light on the evolution of RNA-mediated gene silencing and have implications for the adaptation of such silencing strategies for various purposes.


Citation: Xie Z, Johansen LK, Gustafson AM, Kasschau KD, Lellis AD, et al. (2004) Genetic and functional diversification of small RNA pathways in plants. PLoS Biol 2(5): e104 DOI: 10.1371/journal.pbio.0020104

CONTACTS:
James Carrington
Oregon State University
Corvallis, OR 97331
United States of America
541-737-3686
carrington@orst.edu

Steven Jacobsen
University of California, Los Angeles
Los Angeles, California 90095-1606
United States of America
310-825-0182
jacobsen@ucla.edu

This article is presented as a pre-issue publication. It will be part of our May 2004 issue.

Philip Bernstein | EurekAlert!
Further information:
http://www.plosbiology.org/plosonline/?request=get-document&doi=10.1371/journal.pbio.0020104
http://www.plosbiology.org/plosonline/?request=get-document&doi=10.1371/journal.pbio.0020028

More articles from Life Sciences:

nachricht Overlooked molecular machine in cell nucleus may hold key to treating aggressive leukemia
23.04.2019 | Cincinnati Children's Hospital Medical Center

nachricht Bacteria use their enemy -- phage -- for 'self-recognition'
23.04.2019 | Chinese Academy of Sciences Headquarters

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Quantum gas turns supersolid

Researchers led by Francesca Ferlaino from the University of Innsbruck and the Austrian Academy of Sciences report in Physical Review X on the observation of supersolid behavior in dipolar quantum gases of erbium and dysprosium. In the dysprosium gas these properties are unprecedentedly long-lived. This sets the stage for future investigations into the nature of this exotic phase of matter.

Supersolidity is a paradoxical state where the matter is both crystallized and superfluid. Predicted 50 years ago, such a counter-intuitive phase, featuring...

Im Focus: Explosion on Jupiter-sized star 10 times more powerful than ever seen on our sun

A stellar flare 10 times more powerful than anything seen on our sun has burst from an ultracool star almost the same size as Jupiter

  • Coolest and smallest star to produce a superflare found
  • Star is a tenth of the radius of our Sun
  • Researchers led by University of Warwick could only see...

Im Focus: Quantum simulation more stable than expected

A localization phenomenon boosts the accuracy of solving quantum many-body problems with quantum computers which are otherwise challenging for conventional computers. This brings such digital quantum simulation within reach on quantum devices available today.

Quantum computers promise to solve certain computational problems exponentially faster than any classical machine. “A particularly promising application is the...

Im Focus: Largest, fastest array of microscopic 'traffic cops' for optical communications

The technology could revolutionize how information travels through data centers and artificial intelligence networks

Engineers at the University of California, Berkeley have built a new photonic switch that can control the direction of light passing through optical fibers...

Im Focus: A long-distance relationship in femtoseconds

Physicists observe how electron-hole pairs drift apart at ultrafast speed, but still remain strongly bound.

Modern electronics relies on ultrafast charge motion on ever shorter length scales. Physicists from Regensburg and Gothenburg have now succeeded in resolving a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Revered mathematicians and computer scientists converge with 200 young researchers in Heidelberg!

17.04.2019 | Event News

First dust conference in the Central Asian part of the earth’s dust belt

15.04.2019 | Event News

Fraunhofer FHR at the IEEE Radar Conference 2019 in Boston, USA

09.04.2019 | Event News

 
Latest News

Marine Skin dives deeper for better monitoring

23.04.2019 | Information Technology

Geomagnetic jerks finally reproduced and explained

23.04.2019 | Earth Sciences

Overlooked molecular machine in cell nucleus may hold key to treating aggressive leukemia

23.04.2019 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>