A subtle structural change that may play a role in the molecular machinery for making HIV-1 (the virus that causes AIDS) has been identified by scientists from the National Institute of Standards and Technology (NIST) and University of Maryland working at the Center for Advanced Research in Biotechnology (CARB). If confirmed in living cells, the mechanism, described in the Jan. 20 online edition of Proceedings of the National Academy of Sciences, might provide a new target for antiviral drugs.
The finding is among several to emerge recently from CARBs efforts to develop and validate sensitive tools for rapidly detecting and quantifying ribonucleic acid (RNA) interactions. RNA provides the genetic blueprint for retroviruses such as HIV-1. CARB scientists created a model system for tracking changes in an RNA structural element involved in forming HIV-1 viral particles.
As new HIV-1 viruses form and mature into infectious particles, two strands of RNA interact through a transient structure called a "molecular kiss." This structure is then packaged into new virus particles, which undergo further maturation after release from the infected cell. CARB scientists found that specific sites in the "kissing" structure acquire a proton (a positively charged particle) at a pH close to that of living cells. The protons presence alters the RNA structure and accelerates its refolding by a protein associated with viral maturation. Taken together, these observations suggest that such a mechanism might be at work during viral infection.
Laura Ost | EurekAlert!
A novel synthetic antibody enables conditional “protein knockdown” in vertebrates
20.08.2018 | Technische Universität Dresden
Climate Impact Research in Hannover: Small Plants against Large Waves
17.08.2018 | Leibniz Universität Hannover
There are currently great hopes for solid-state batteries. They contain no liquid parts that could leak or catch fire. For this reason, they do not require cooling and are considered to be much safer, more reliable, and longer lasting than traditional lithium-ion batteries. Jülich scientists have now introduced a new concept that allows currents up to ten times greater during charging and discharging than previously described in the literature. The improvement was achieved by a “clever” choice of materials with a focus on consistently good compatibility. All components were made from phosphate compounds, which are well matched both chemically and mechanically.
The low current is considered one of the biggest hurdles in the development of solid-state batteries. It is the reason why the batteries take a relatively long...
New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference
Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
17.08.2018 | Event News
08.08.2018 | Event News
27.07.2018 | Event News
20.08.2018 | Information Technology
20.08.2018 | Life Sciences
20.08.2018 | Information Technology