Biologists at the University of California, San Diego and the Johns Hopkins University have discovered a gene that plays a key role in initiating changes in the brain in response to sensory experience, a finding that may provide insight into certain types of learning disorders.
Images of neurons from normal mice (left) and from mice lacking CREST gene (right) Credit: Anirvan Ghosh
After birth, learning and experience change the architecture of the brain dramatically. The structure of individual neurons, or nerve cells, changes during learning to accommodate new connections between neurons. Neuroscientists believe these structural changes are initiated when neurons are activated, causing calcium ions to flow into cells and alter the activity of genes.
In a paper featured on the cover of the January 9th issue of the journal Science, biologists at UCSD and the Johns Hopkins University medical school report the discovery of the first gene, CREST, known to mediate these changes in the structure of neurons in response to calcium.
Sherry Seethaler | UCSD
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