Credit: Thomas Park of UIC
East African naked mole-rats, the only known cold-blooded mammal, have shown a rather heated response in lab tests that may have important implications for treating chronic pain in humans.
The blind, furless creatures that live underground in colonies lack a body chemical called Substance P, a neurotransmitter normally in the skin that sends pain signals to the central nervous system. The rats feel no immediate pain when cut, scraped or subjected to heat stimuli. They only feel some aches. But when the rats get a shot of Substance P, pain signaling resumes working as in other mammals.
"It was a complete surprise when we discovered that the skin of naked mole-rats is missing one of the most basic chemicals that’s found in the skin of all other mammals," said Thomas Park, associate professor of biological sciences at the University of Illinois at Chicago and the principal investigator in the research project.
Paul Francuch | UIC
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