Despite the rich knowledge scientists now have of the genes that constitute the human genome, researchers have yet to unravel the precise choreography by which they work – or malfunction – together in the cell in response to triggers from the outside world.
"There is a code we need to understand to determine what happens to a cell under many different conditions, and ultimately to make predictions of how an entire genome is regulated," explains Julia Zeitlinger, a postdoctoral associate at Whitehead Institute for Biomedical Research.
Key to cracking this code, she says, is a set of proteins called transcription factors, which bind to specific genes to produce proteins. Akin to computer programs that return different results depending on the input data, transcription factors can carry out multiple functions in the cell in response to distinct stimuli.
Kelli Whitlock | EurekAlert!
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Different eras of civilization are defined by the discovery of new materials, as new materials drive new capabilities. And yet, identifying the best material...
Researchers from the University of Basel have reported a new method that allows the physical state of just a few atoms or molecules within a network to be controlled. It is based on the spontaneous self-organization of molecules into extensive networks with pores about one nanometer in size. In the journal ‘small’, the physicists reported on their investigations, which could be of particular importance for the development of new storage devices.
Around the world, researchers are attempting to shrink data storage devices to achieve as large a storage capacity in as small a space as possible. In almost...
The more objects we make "smart," from watches to entire buildings, the greater the need for these devices to store and retrieve massive amounts of data quickly without consuming too much power.
Millions of new memory cells could be part of a computer chip and provide that speed and energy savings, thanks to the discovery of a previously unobserved...
What if, instead of turning up the thermostat, you could warm up with high-tech, flexible patches sewn into your clothes - while significantly reducing your...
A widely used diabetes medication combined with an antihypertensive drug specifically inhibits tumor growth – this was discovered by researchers from the University of Basel’s Biozentrum two years ago. In a follow-up study, recently published in “Cell Reports”, the scientists report that this drug cocktail induces cancer cell death by switching off their energy supply.
The widely used anti-diabetes drug metformin not only reduces blood sugar but also has an anti-cancer effect. However, the metformin dose commonly used in the...
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