Identification of Jelly Belly gene may lead to new drugs to combat heart disease, cancer and neurological disorders
Researchers at Oregon Health & Science University (OHSU) have identified a secreted signaling protein that regulates smooth muscle development in fruit flies. In the absence of a protein called "Jelly Belly (Jeb)," primitive smooth muscle cells fail to migrate or differentiate, according to study results published in the October 2 issue of Nature.
"Our research shows that Jelly Belly is required for the normal development of the smooth muscle that surrounds the gut in flies and we are investigating it in the arteries of mammals. It is also related to the development of heart muscle," said Joseph B. Weiss M.D., Ph.D., principal investigator and assistant professor (molecular medicine and cardiology), and Heart Research Center scientist in the OHSU School of Medicine.
Smooth muscles are involved in involuntary but essential functions, such as digestion and control of blood flow. Unlocking the genetic mechanisms controlling their embryonic development may allow scientists to understand better what triggers their abnormal growth. Human disorders that are linked to abnormal smooth muscle growth or function include high blood pressure, arteriosclerosis and congenital heart defects.
Christine Pashley | EurekAlert!
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An international team with the participation of Prof. Dr. Michael Kues from the Cluster of Excellence PhoenixD at Leibniz University Hannover has developed a new method for generating quantum-entangled photons in a spectral range of light that was previously inaccessible. The discovery can make the encryption of satellite-based communications much more secure in the future.
A 15-member research team from the UK, Germany and Japan has developed a new method for generating and detecting quantum-entangled photons at a wavelength of...
Together with their colleagues from the University of Würzburg, physicists from the group of Professor Alexander Szameit at the University of Rostock have devised a “funnel” for photons. Their discovery was recently published in the renowned journal Science and holds great promise for novel ultra-sensitive detectors as well as innovative applications in telecommunications and information processing.
The quantum-optical properties of light and its interaction with matter has fascinated the Rostock professor Alexander Szameit since College.
Researchers at the University of Zurich show that different stem cell populations are innervated in distinct ways. Innervation may therefore be crucial for proper tissue regeneration. They also demonstrate that cancer stem cells likewise establish contacts with nerves. Targeting tumour innervation could thus lead to new cancer therapies.
Stem cells can generate a variety of specific tissues and are increasingly used for clinical applications such as the replacement of bone or cartilage....
An international research team led by Kiel University develops an extremely porous material made of "white graphene" for new laser light applications
With a porosity of 99.99 %, it consists practically only of air, making it one of the lightest materials in the world: Aerobornitride is the name of the...
Researchers at Graz University of Technology have developed a framework by which wireless devices with different radio technologies will be able to communicate directly with each other.
Whether networked vehicles that warn of traffic jams in real time, household appliances that can be operated remotely, "wearables" that monitor physical...
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31.03.2020 | Life Sciences
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31.03.2020 | Medical Engineering