Predisposition to many common diseases – among which cancer, cardiovascular conditions, diabetes, asthma, etc. – is said to be a multifactor phenomenon as it results from numerous genes as well as environmental factors. Identifying such predisposition genes is one of the major challenges in modern genetics and could contribute to establishing new preventive medicine patterns and developing new specific drugs.
However, the identification of predisposition genes appeared to be extremely difficult in humans. Despite huge investments, “successes” can be counted on the fingers of one hand.
Considering our domestic animals’ history, such populations are particularly well-adapted to the analysis of multifactor characters. This was shown most dramatically by the recent identification of a mutation in an IGF2 gene regulatory element leading to a muscle mass increase in pigs. A particularly ingenious genetic analysis allowed experts to isolate the relevant mutation among 280 other mutations identified in the gene. Functional analyses subsequently indicated that the mutation inactivated an inhibitor of the IGF2 production in muscles. As a consequence, it increased IGF2 secretion and muscle growth.
Didier Moreau | alfa
How algae and carbon fibers could sustainably reduce the athmospheric carbon dioxide concentration
14.11.2018 | Technische Universität München
NIH scientists illuminate causes of hepatitis b virus-associated acute liver failure
14.11.2018 | NIH/National Institute of Allergy and Infectious Diseases
Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...
Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...
On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure
Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...
Physicists at ETH Zurich demonstrate how errors that occur during the manipulation of quantum system can be monitored and corrected on the fly
The field of quantum computation has seen tremendous progress in recent years. Bit by bit, quantum devices start to challenge conventional computers, at least...
09.11.2018 | Event News
06.11.2018 | Event News
23.10.2018 | Event News
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14.11.2018 | Earth Sciences
14.11.2018 | Medical Engineering