Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Aging brain reduces ovulation

10.10.2003


Dutch researcher Annelieke Franke has discovered that the aging of the brain adversely affects the fertility of female rats. The scientist suspects that her research will provide insights into fertility problems of women over the age of 30.



Franke studied relatively young subfertile rats. Although the pituitary gland and ovaries of these rats still functioned normally, their brains had already started to function differently. This led Franke to conclude that the ageing of the brain reduces fertility.

Generally speaking, human brains regulate the reproductive system in the same manner as rat brains. However, an important difference is that rats still posses a significant number of oocytes after the fertile period, whereas in humans the supply is considerably depleted. This reduced supply of oocytes is the most important limiting factor for fertility in older women.


Despite this difference between humans and rats, the researcher still expects that the ageing of the brain in humans also plays a role in age-dependent reduced fertility. This knowledge could help to develop treatments for relatively young women who are subfertile. The fertility of women decreases from about the age of 30 years onwards. This can be problematic for women who wish to have a career before they have children.

Ovulation of oocytes is one of the reproductive cycle factors that is regulated by the brain. An initiating signal from the brain instructs the pituitary gland to produce more luteinising hormone (LH). A feedback mechanism from the ovaries to the brain ensures that ovulation only occurs when the follicles and oocytes are mature. Matured follicles produce large quantities of oestrogen. The brain responds to this and initiates ovulation.

The researcher revealed that this feedback mechanism no longer functions optimally in older female rats. Although the oestrogen concentrations in the blood had not changed with age, less receptors for oestrogen and progesterone were present in specific areas of the brain. Furthermore, older rats released less LH than younger rats.

High oestrogen concentrations normally lead to an increase in the number of progesterone receptors. These receptors are crucial for the occurrence of the peak in LH release. Older brains seem to be less sensitive to oestrogen. As a result of this, the LH peak attenuates and the fertility decreases.

Sonja Jacobs | alfa
Further information:
http://www.nwo.nl

More articles from Life Sciences:

nachricht Solving the efficiency of Gram-negative bacteria
22.03.2019 | Harvard University

nachricht Bacteria bide their time when antibiotics attack
22.03.2019 | Rice University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: The taming of the light screw

DESY and MPSD scientists create high-order harmonics from solids with controlled polarization states, taking advantage of both crystal symmetry and attosecond electronic dynamics. The newly demonstrated technique might find intriguing applications in petahertz electronics and for spectroscopic studies of novel quantum materials.

The nonlinear process of high-order harmonic generation (HHG) in gases is one of the cornerstones of attosecond science (an attosecond is a billionth of a...

Im Focus: Magnetic micro-boats

Nano- and microtechnology are promising candidates not only for medical applications such as drug delivery but also for the creation of little robots or flexible integrated sensors. Scientists from the Max Planck Institute for Polymer Research (MPI-P) have created magnetic microparticles, with a newly developed method, that could pave the way for building micro-motors or guiding drugs in the human body to a target, like a tumor. The preparation of such structures as well as their remote-control can be regulated using magnetic fields and therefore can find application in an array of domains.

The magnetic properties of a material control how this material responds to the presence of a magnetic field. Iron oxide is the main component of rust but also...

Im Focus: Self-healing coating made of corn starch makes small scratches disappear through heat

Due to the special arrangement of its molecules, a new coating made of corn starch is able to repair small scratches by itself through heat: The cross-linking via ring-shaped molecules makes the material mobile, so that it compensates for the scratches and these disappear again.

Superficial micro-scratches on the car body or on other high-gloss surfaces are harmless, but annoying. Especially in the luxury segment such surfaces are...

Im Focus: Stellar cartography

The Potsdam Echelle Polarimetric and Spectroscopic Instrument (PEPSI) at the Large Binocular Telescope (LBT) in Arizona released its first image of the surface magnetic field of another star. In a paper in the European journal Astronomy & Astrophysics, the PEPSI team presents a Zeeman- Doppler-Image of the surface of the magnetically active star II Pegasi.

A special technique allows astronomers to resolve the surfaces of faraway stars. Those are otherwise only seen as point sources, even in the largest telescopes...

Im Focus: Heading towards a tsunami of light

Researchers at Chalmers University of Technology and the University of Gothenburg, Sweden, have proposed a way to create a completely new source of radiation. Ultra-intense light pulses consist of the motion of a single wave and can be described as a tsunami of light. The strong wave can be used to study interactions between matter and light in a unique way. Their research is now published in the scientific journal Physical Review Letters.

"This source of radiation lets us look at reality through a new angle - it is like twisting a mirror and discovering something completely different," says...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

International Modelica Conference with 330 visitors from 21 countries at OTH Regensburg

11.03.2019 | Event News

Selection Completed: 580 Young Scientists from 88 Countries at the Lindau Nobel Laureate Meeting

01.03.2019 | Event News

LightMAT 2019 – 3rd International Conference on Light Materials – Science and Technology

28.02.2019 | Event News

 
Latest News

Solving the efficiency of Gram-negative bacteria

22.03.2019 | Life Sciences

Bacteria bide their time when antibiotics attack

22.03.2019 | Life Sciences

Open source software helps researchers extract key insights from huge sensor datasets

22.03.2019 | Information Technology

VideoLinks
Science & Research
Overview of more VideoLinks >>>