A naturally occurring variation in an essential gene can suppress genetic mutations caused by retroviruses in mice, according to a new discovery by researchers at the University of California, San Diego (UCSD) School of Medicine.
Published in the September 28 online edition of Nature Genetics, and in the journal’s October issue, the study identified a novel change in mice in a gene called mRNA nuclear export factor 1 (Nxf1). This gene normally acts as part of the cell’s machinery for ensuring that only properly functioning genes are expressed, or turned on. Genes that have been disrupted by insertions of retroviruses often fail to pass this quality checkpoint.
The UCSD team demonstrated that the novel form of Nxf1 restored function to mutated genes by increasing the amount of normal product made by the mutated gene, and alleviated abnormalities in two very different mouse mutations.
Sue Pondrom | UCSD news
Microscope measures muscle weakness
16.11.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg
Good preparation is half the digestion
16.11.2018 | Max-Planck-Institut für Stoffwechselforschung
Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.
Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...
Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...
Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...
On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure
Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...
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16.11.2018 | Life Sciences