A signal that triggers half the stem cells in the developing brain to commit suicide at a stage where their survival will likely do more harm than good has been identified by researchers at the Medical College of Georgia and the University of Georgia.
Identifying the factors that result in the timely, massive cell suicide is important to understanding the developmental puzzle, the researchers say of the work featured on the cover of the Aug. 4 issue of the Journal of Cell Biology.
They say it also gives clues about cell death - and the brain´s possible recovery - in devastating diseases such as Alzheimer´s, Parkinson´s and stroke. MCG´s Erhard Bieberich and UGA´s Brian G. Condie have found that the lipid ceramide and the protein PAR-4 - each already implicated for playing a role in cell death - become deadly partners inside a dividing stem cell in the developing mouse brain.
Phil Williams | EurekAlert!
New image of a cancer-related enzyme in action helps explain gene regulation
05.06.2020 | Penn State
Protecting the Neuronal Architecture
05.06.2020 | Universität Heidelberg
Humans rely dominantly on their eyesight. Losing vision means not being able to read, recognize faces or find objects. Macular degeneration is one of the major...
In meningococci, the RNA-binding protein ProQ plays a major role. Together with RNA molecules, it regulates processes that are important for pathogenic properties of the bacteria.
Meningococci are bacteria that can cause life-threatening meningitis and sepsis. These pathogens use a small protein with a large impact: The RNA-binding...
An analysis of more than 200,000 spiral galaxies has revealed unexpected links between spin directions of galaxies, and the structure formed by these links...
Two prominent X-ray emission lines of highly charged iron have puzzled astrophysicists for decades: their measured and calculated brightness ratios always disagree. This hinders good determinations of plasma temperatures and densities. New, careful high-precision measurements, together with top-level calculations now exclude all hitherto proposed explanations for this discrepancy, and thus deepen the problem.
Hot astrophysical plasmas fill the intergalactic space, and brightly shine in stellar coronae, active galactic nuclei, and supernova remnants. They contain...
In living cells, enzymes drive biochemical metabolic processes enabling reactions to take place efficiently. It is this very ability which allows them to be used as catalysts in biotechnology, for example to create chemical products such as pharmaceutics. Researchers now identified an enzyme that, when illuminated with blue light, becomes catalytically active and initiates a reaction that was previously unknown in enzymatics. The study was published in "Nature Communications".
Enzymes: they are the central drivers for biochemical metabolic processes in every living cell, enabling reactions to take place efficiently. It is this very...
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05.06.2020 | Life Sciences