A multi-institutional team of scientists has gained important new knowledge about the regulatory role played in Alzheimer’s disease by Pin1, a protein that coaxes other proteins into untwisting. The research is published in the July 31 issue of Nature.
The team of researchers, including a group from the Department of Human Genetics at Emory University School of Medicine, examined slices of brain and found an inverse relationship between the abundance of Pin1 and both the susceptibility of neurons to degenerative damage and the amount of protein tangles. They also found that mice with an artificial disruption of Pin1 develop a neurodegenerative disease that resembles Alzheimer’s.
Lead authors are Drs. Yih-cherng Liou, Anyang Sun, and Kun Ping Lu from Harvard Medical School. Xiaojiang Li, PhD and Zhao-Xue Yu, PhD from Emory School of Medicine studied the degeneration in the brains of Pin1-deficient mice using electron microscopy and immunogold staining. Scientists from the University of Kentucky, the Salk Institute, and Tufts University also contributed to the study.
Holly Korschun | EurekAlert!
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Flexible, organic and printed electronics conquer everyday life. The forecasts for growth promise increasing markets and opportunities for the industry. In Europe, top institutions and companies are engaged in research and further development of these technologies for tomorrow's markets and applications. However, access by SMEs is difficult. The European project SmartEEs - Smart Emerging Electronics Servicing works on the establishment of a European innovation network, which supports both the access to competences as well as the support of the enterprises with the assumption of innovations and the progress up to the commercialization.
It surrounds us and almost unconsciously accompanies us through everyday life - printed electronics. It starts with smart labels or RFID tags in clothing, we...
The human eye is particularly sensitive to green, but less sensitive to blue and red. Chemists led by Hubert Huppertz at the University of Innsbruck have now developed a new red phosphor whose light is well perceived by the eye. This increases the light yield of white LEDs by around one sixth, which can significantly improve the energy efficiency of lighting systems.
Light emitting diodes or LEDs are only able to produce light of a certain colour. However, white light can be created using different colour mixing processes.
Researchers led by Francesca Ferlaino from the University of Innsbruck and the Austrian Academy of Sciences report in Physical Review X on the observation of supersolid behavior in dipolar quantum gases of erbium and dysprosium. In the dysprosium gas these properties are unprecedentedly long-lived. This sets the stage for future investigations into the nature of this exotic phase of matter.
Supersolidity is a paradoxical state where the matter is both crystallized and superfluid. Predicted 50 years ago, such a counter-intuitive phase, featuring...
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A localization phenomenon boosts the accuracy of solving quantum many-body problems with quantum computers which are otherwise challenging for conventional computers. This brings such digital quantum simulation within reach on quantum devices available today.
Quantum computers promise to solve certain computational problems exponentially faster than any classical machine. “A particularly promising application is the...
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