Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Estrogen withdrawal results in bone loss, research shows that the Estrogen Receptor has a fundamental role

25.07.2003


Professor Lance Lanyon, Principal of The Royal Veterinary College, Karla Lee, Helen Jessop, Rosemary Suswillo, Gul Zaman from the Department of Basic Sciences at The Royal Veterinary College have shown in their research that the Estrogen Receptor has a fundamental role in bone cells by adjusting the bone architecture to match the loads individuals place on them. Their paper is published in the latest edition of Nature.



The strain imposed by mechanical loading on bone tissue normally stimulates a response by bone cells that results in an adjustment to bone architecture and enables the bone to withstand reasonable loads. This research centred on why this process should become less effective in some 50 per cent of post-menopausal women who suffered fractures as a result.

This research shows why estrogen withdrawal results in bone loss – the number of Estrogen Receptors is reduced by the estrogen levels. When estrogen levels decline (as at menopause) ER levels also decline to the extent that they limit the bone cells’ adaptive responses to load bearing thus producing an effective environment of disuse or underuse which permits bone loss.


Previous research has concentrated on the effects of estrogen on various processes assuming the Estrogen Receptor is more or less constant. One of the Estrogen Receptor’s possible early reproductive functions may be to induce skeletal remodelling to release calcium for egg-laying or embyonic delvelopment.

Professor Lanyon says: "the ER is amenable to therapy and there may be a way either to regulate it in bone or to affect its activity. For instance Hormone Replacement Therapy will restore the ER number and thus eliminate the restriction on the loading-related response."

Virginia Fisher | alfa
Further information:
http://www.rvc.ac.uk

More articles from Life Sciences:

nachricht Microbes can grow on nitric oxide (NO)
18.03.2019 | Max-Planck-Institut für Marine Mikrobiologie

nachricht Novel methods for analyzing neural circuits for innate behaviors in insects
15.03.2019 | Kanazawa University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Revealing the secret of the vacuum for the first time

New research group at the University of Jena combines theory and experiment to demonstrate for the first time certain physical processes in a quantum vacuum

For most people, a vacuum is an empty space. Quantum physics, on the other hand, assumes that even in this lowest-energy state, particles and antiparticles...

Im Focus: Sussex scientists one step closer to a clock that could replace GPS and Galileo

Physicists in the EPic Lab at University of Sussex make crucial development in global race to develop a portable atomic clock

Scientists in the Emergent Photonics Lab (EPic Lab) at the University of Sussex have made a breakthrough to a crucial element of an atomic clock - devices...

Im Focus: Sensing shakes

A new way to sense earthquakes could help improve early warning systems

Every year earthquakes worldwide claim hundreds or even thousands of lives. Forewarning allows people to head for safety and a matter of seconds could spell...

Im Focus: A thermo-sensor for magnetic bits

New concept for energy-efficient data processing technology

Scientists of the Department of Physics at the University of Hamburg, Germany, detected the magnetic states of atoms on a surface using only heat. The...

Im Focus: The moiré patterns of three layers change the electronic properties of graphene

Combining an atomically thin graphene and a boron nitride layer at a slightly rotated angle changes their electrical properties. Physicists at the University of Basel have now shown for the first time the combination with a third layer can result in new material properties also in a three-layer sandwich of carbon and boron nitride. This significantly increases the number of potential synthetic materials, report the researchers in the scientific journal Nano Letters.

Last year, researchers in the US caused a big stir when they showed that rotating two stacked graphene layers by a “magical” angle of 1.1 degrees turns...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

International Modelica Conference with 330 visitors from 21 countries at OTH Regensburg

11.03.2019 | Event News

Selection Completed: 580 Young Scientists from 88 Countries at the Lindau Nobel Laureate Meeting

01.03.2019 | Event News

LightMAT 2019 – 3rd International Conference on Light Materials – Science and Technology

28.02.2019 | Event News

 
Latest News

Researchers measure near-perfect performance in low-cost semiconductors

18.03.2019 | Power and Electrical Engineering

Nanocrystal 'factory' could revolutionize quantum dot manufacturing

18.03.2019 | Materials Sciences

Long-distance quantum information exchange -- success at the nanoscale

18.03.2019 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>