Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Estrogen withdrawal results in bone loss, research shows that the Estrogen Receptor has a fundamental role

25.07.2003


Professor Lance Lanyon, Principal of The Royal Veterinary College, Karla Lee, Helen Jessop, Rosemary Suswillo, Gul Zaman from the Department of Basic Sciences at The Royal Veterinary College have shown in their research that the Estrogen Receptor has a fundamental role in bone cells by adjusting the bone architecture to match the loads individuals place on them. Their paper is published in the latest edition of Nature.



The strain imposed by mechanical loading on bone tissue normally stimulates a response by bone cells that results in an adjustment to bone architecture and enables the bone to withstand reasonable loads. This research centred on why this process should become less effective in some 50 per cent of post-menopausal women who suffered fractures as a result.

This research shows why estrogen withdrawal results in bone loss – the number of Estrogen Receptors is reduced by the estrogen levels. When estrogen levels decline (as at menopause) ER levels also decline to the extent that they limit the bone cells’ adaptive responses to load bearing thus producing an effective environment of disuse or underuse which permits bone loss.


Previous research has concentrated on the effects of estrogen on various processes assuming the Estrogen Receptor is more or less constant. One of the Estrogen Receptor’s possible early reproductive functions may be to induce skeletal remodelling to release calcium for egg-laying or embyonic delvelopment.

Professor Lanyon says: "the ER is amenable to therapy and there may be a way either to regulate it in bone or to affect its activity. For instance Hormone Replacement Therapy will restore the ER number and thus eliminate the restriction on the loading-related response."

Virginia Fisher | alfa
Further information:
http://www.rvc.ac.uk

More articles from Life Sciences:

nachricht New yeast species discovered in Braunschweig, Germany
13.12.2019 | Leibniz-Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH

nachricht Saliva test shows promise for earlier and easier detection of mouth and throat cancer
13.12.2019 | Elsevier

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Virus multiplication in 3D

Vaccinia viruses serve as a vaccine against human smallpox and as the basis of new cancer therapies. Two studies now provide fascinating insights into their unusual propagation strategy at the atomic level.

For viruses to multiply, they usually need the support of the cells they infect. In many cases, only in their host’s nucleus can they find the machines,...

Im Focus: Cheers! Maxwell's electromagnetism extended to smaller scales

More than one hundred and fifty years have passed since the publication of James Clerk Maxwell's "A Dynamical Theory of the Electromagnetic Field" (1865). What would our lives be without this publication?

It is difficult to imagine, as this treatise revolutionized our fundamental understanding of electric fields, magnetic fields, and light. The twenty original...

Im Focus: Highly charged ion paves the way towards new physics

In a joint experimental and theoretical work performed at the Heidelberg Max Planck Institute for Nuclear Physics, an international team of physicists detected for the first time an orbital crossing in the highly charged ion Pr⁹⁺. Optical spectra were recorded employing an electron beam ion trap and analysed with the aid of atomic structure calculations. A proposed nHz-wide transition has been identified and its energy was determined with high precision. Theory predicts a very high sensitivity to new physics and extremely low susceptibility to external perturbations for this “clock line” making it a unique candidate for proposed precision studies.

Laser spectroscopy of neutral atoms and singly charged ions has reached astonishing precision by merit of a chain of technological advances during the past...

Im Focus: Ultrafast stimulated emission microscopy of single nanocrystals in Science

The ability to investigate the dynamics of single particle at the nano-scale and femtosecond level remained an unfathomed dream for years. It was not until the dawn of the 21st century that nanotechnology and femtoscience gradually merged together and the first ultrafast microscopy of individual quantum dots (QDs) and molecules was accomplished.

Ultrafast microscopy studies entirely rely on detecting nanoparticles or single molecules with luminescence techniques, which require efficient emitters to...

Im Focus: How to induce magnetism in graphene

Graphene, a two-dimensional structure made of carbon, is a material with excellent mechanical, electronic and optical properties. However, it did not seem suitable for magnetic applications. Together with international partners, Empa researchers have now succeeded in synthesizing a unique nanographene predicted in the 1970s, which conclusively demonstrates that carbon in very specific forms has magnetic properties that could permit future spintronic applications. The results have just been published in the renowned journal Nature Nanotechnology.

Depending on the shape and orientation of their edges, graphene nanostructures (also known as nanographenes) can have very different properties – for example,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

The Future of Work

03.12.2019 | Event News

First International Conference on Agrophotovoltaics in August 2020

15.11.2019 | Event News

Laser Symposium on Electromobility in Aachen: trends for the mobility revolution

15.11.2019 | Event News

 
Latest News

Supporting structures of wind turbines contribute to wind farm blockage effect

13.12.2019 | Physics and Astronomy

Chinese team makes nanoscopy breakthrough

13.12.2019 | Physics and Astronomy

Tiny quantum sensors watch materials transform under pressure

13.12.2019 | Materials Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>