Researchers from Cornell University have developed a miniaturized DNA-based biological testing system that fits on a silicon chip and can be customized to detect a wide variety of microorganisms. They present their research today at the American Society for Microbiology’s (ASM) Conference on Bio- Micro- Nano-systems.
The chip consists of two areas. The first area captures the DNA from the sample and purifies it. The second is a reaction chamber where a process called polymerase chain reaction is performed to rapidly replicate the selected segment of DNA, which can then be tested.
"Other people have developed real-time PCR on silicon chips, but nobody has really done the purification of the DNA sample on the same chip," says Nathan Cady, one of the researchers on the study. "As near as we can tell, we are one of the first groups to incorporate the purification step into the chip."
Jim Sliwa | EurekAlert!
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