Researchers looking inside a pathogenic soil bacterium have found an organelle, a subcellular pouch, existing independently from the plasma membrane. The discovery within a prokaryotic organism challenges the theory on the origin of eukaryotic organelles and suggests a targeted approach to killing many disease-causing organisms.
Acidocalcisomes (the black spheres) as viewed in a trypanosome, a family of parasites that cause African sleeping sickness, Chagas disease and leishmaniasis and the first organisms where Docampo found this organelle. The cell is approximately 10 microns long and 4 microns wide. Courtesy of Kildare Miranda
"The organelle we found in the bacterium Agrobacterium tumefaciens is practically identical to the organelle called acidocalcisome in unicellular eukaryotes," said Roberto Docampo, a professor of veterinary pathobiology in the College of Veterinary Medicine at the University of Illinois at Urbana-Champaign.
Docampo began researching these organelles in 1994. He soon determined that a tiny granule in yeast, fungi and bacteria, thought to be for storage, was a fully operational organelle containing pyrophosphatase, a pump-like enzyme that allows proton transport. He named it an acidocalcisome for its acidic and calcium components. In 2000, he reported its existence in Plasmodium berghei, a malaria-causing eukaryotic parasite.
Jim Barlow | UIUC
Climate Impact Research in Hannover: Small Plants against Large Waves
17.08.2018 | Leibniz Universität Hannover
First transcription atlas of all wheat genes expands prospects for research and cultivation
17.08.2018 | Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung
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Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
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Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
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