Scientists from the RIKEN Tsukuba Institute (Japan) have developed a valuable new experimental system for tissue-specific RNAi knockdown in mammalian cells and organisms – a discovery that will markedly advance the functional characterization of genes involved in development and disease.
Discovered in the late nineties, RNA intereference (RNAi) refers to the introduction of double-stranded RNA (dsRNA) into a cell, where it induces the degradation of complementary mRNA, and thereby suppresses gene expression. RNAi has proven to be a powerful tool in the elucidation of gene function in organisms ranging from worms, to plants and fruit flies.
However, the use of RNAi in mammals has been complicated by the antiviral response of mammalian cells to dsRNA. The presence of foreign dsRNA in a mammalian cell initiates the so-called "interferon response:" the non-specific degradation of mRNA, and ensuing death of the cell. Mammalian RNAi researchers have undertaken a few different routes to avoid eliciting the interferon response, and while some have been successful, none have been able to accomplish it in a tissue-specific manner. Until now.
Heather Cosel | EurekAlert!
Small but versatile; key players in the marine nitrogen cycle can utilize cyanate and urea
10.12.2018 | Max-Planck-Institut für Marine Mikrobiologie
Carnegie Mellon researchers probe hydrogen bonds using new technique
10.12.2018 | Carnegie Mellon University
What if a sensor sensing a thing could be part of the thing itself? Rice University engineers believe they have a two-dimensional solution to do just that.
Rice engineers led by materials scientists Pulickel Ajayan and Jun Lou have developed a method to make atom-flat sensors that seamlessly integrate with devices...
Scientists at the University of Stuttgart and the Karlsruhe Institute of Technology (KIT) succeed in important further development on the way to quantum Computers.
Quantum computers one day should be able to solve certain computing problems much faster than a classical computer. One of the most promising approaches is...
New Project SNAPSTER: Novel luminescent materials by encapsulating phosphorescent metal clusters with organic liquid crystals
Nowadays energy conversion in lighting and optoelectronic devices requires the use of rare earth oxides.
Scientists have discovered the first synthetic material that becomes thicker - at the molecular level - as it is stretched.
Researchers led by Dr Devesh Mistry from the University of Leeds discovered a new non-porous material that has unique and inherent "auxetic" stretching...
Scientists from the Theory Department of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science (CFEL) in Hamburg have shown through theoretical calculations and computer simulations that the force between electrons and lattice distortions in an atomically thin two-dimensional superconductor can be controlled with virtual photons. This could aid the development of new superconductors for energy-saving devices and many other technical applications.
The vacuum is not empty. It may sound like magic to laypeople but it has occupied physicists since the birth of quantum mechanics.
10.12.2018 | Event News
06.12.2018 | Event News
03.12.2018 | Event News
10.12.2018 | Life Sciences
10.12.2018 | Physics and Astronomy
10.12.2018 | Life Sciences