Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers identify protein which could help protect against neuro-degenerative conditions

30.05.2003


Protein could be used as a treatment for Alzheimer’s, Parkinson’s, and Huntington’s disease



A team of researchers from Imperial College London, the Charing Cross Hospital and University College London have identified a protein which could be used to protect against neuro-degenerative conditions such as Alzheimer’s, Parkinson’s, Huntington’s, motor neurone diseases and the damage caused by strokes.

According to research published today in The Journal of Biological Chemistry, the researchers discovered that the naturally occurring protein, 27-kDa heat shock protein (HSP27) was able to reduce cell death in the brain.


Professor Jacqueline de Belleroche, senior author on the paper, from Imperial College London and the Charing Cross Hospital, comments: "At present, there is no cure for neuro-degenerative diseases, such as Alzheimer’s and Parkinson’s, but the discovery of the beneficial effects of this protein in the brain may provide us with a way to at least slow down the disease process."

For the experiment, the researchers used transgenic mice, which had high levels of HSP27 throughout the brain, spinal cord and other tissues. This was found to reduce mortality rate and neuronal cell death in the hippocampus, a part of the brain affected by neurological diseases. Similar results were also obtained when HSP27 was injected directly into the brain.

Professor de Belleroche adds: "Although this is unlikely to provide a cure for neuro-degenerative disorders, it could be vital in slowing their progress. Eventually it may be possible to use a drug to increase levels of HSP27 in the brain which could be given to those suffering from neuro-degenerative diseases."

Heat shock proteins (HSPs) are a group of proteins present in all cells in all life forms, and are induced when a cell undergoes environmental stresses such as heat, cold and oxygen deprivation.

They are also present in cells under normal conditions, and act like ’chaperones’ to make sure the cell’s proteins are in the right place and shape at the right time.

Tony Stephenson | EurekAlert!
Further information:
http://www.ic.ac.uk/

More articles from Life Sciences:

nachricht Mass spectrometry sheds new light on thallium poisoning cold case
14.12.2018 | University of Maryland

nachricht Protein involved in nematode stress response identified
14.12.2018 | University of Illinois College of Agricultural, Consumer and Environmental Sciences

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Data use draining your battery? Tiny device to speed up memory while also saving power

The more objects we make "smart," from watches to entire buildings, the greater the need for these devices to store and retrieve massive amounts of data quickly without consuming too much power.

Millions of new memory cells could be part of a computer chip and provide that speed and energy savings, thanks to the discovery of a previously unobserved...

Im Focus: An energy-efficient way to stay warm: Sew high-tech heating patches to your clothes

Personal patches could reduce energy waste in buildings, Rutgers-led study says

What if, instead of turning up the thermostat, you could warm up with high-tech, flexible patches sewn into your clothes - while significantly reducing your...

Im Focus: Lethal combination: Drug cocktail turns off the juice to cancer cells

A widely used diabetes medication combined with an antihypertensive drug specifically inhibits tumor growth – this was discovered by researchers from the University of Basel’s Biozentrum two years ago. In a follow-up study, recently published in “Cell Reports”, the scientists report that this drug cocktail induces cancer cell death by switching off their energy supply.

The widely used anti-diabetes drug metformin not only reduces blood sugar but also has an anti-cancer effect. However, the metformin dose commonly used in the...

Im Focus: New Foldable Drone Flies through Narrow Holes in Rescue Missions

A research team from the University of Zurich has developed a new drone that can retract its propeller arms in flight and make itself small to fit through narrow gaps and holes. This is particularly useful when searching for victims of natural disasters.

Inspecting a damaged building after an earthquake or during a fire is exactly the kind of job that human rescuers would like drones to do for them. A flying...

Im Focus: Topological material switched off and on for the first time

Key advance for future topological transistors

Over the last decade, there has been much excitement about the discovery, recognised by the Nobel Prize in Physics only two years ago, that there are two types...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

ICTM Conference 2019: Digitization emerges as an engineering trend for turbomachinery construction

12.12.2018 | Event News

New Plastics Economy Investor Forum - Meeting Point for Innovations

10.12.2018 | Event News

EGU 2019 meeting: Media registration now open

06.12.2018 | Event News

 
Latest News

Data use draining your battery? Tiny device to speed up memory while also saving power

14.12.2018 | Power and Electrical Engineering

Tangled magnetic fields power cosmic particle accelerators

14.12.2018 | Physics and Astronomy

In search of missing worlds, Hubble finds a fast evaporating exoplanet

14.12.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>