Researchers in Oxford University’s Department of Human Anatomy have identified a factor involved in the regeneration of neurons in the central nervous system. The discovery and use of this factor could provide the basis for a reparative treatment for both brain and spinal cord injuries.
Unlike lower vertebrates, mammals have lost the ability to repair damage to the brain and spinal cord. Since peripheral nerves are capable of repair, this is thought to be not so much an intrinsic inability of central nervous system (CNS) tissue to repair itself, but rather an environment in the CNS that is hostile to regeneration. This inhibition of neuronal regeneration is a result of a number of factors including axotomy-induced cell death, a gliotic scar that provides a physical barrier to regeneration as well as an environment that is inhibitory to growth. A number of strategies have been employed in the past to overcome this inhibition, including: blocking apoptosis, stem cell therapy, grafting of peripheral nervous system (PNS) cells and delivery of neurotrophic factors. However, the results of these animal studies have been controversial with regard to their claims of significant functional recovery.
Following a great deal of work on the action of Schwann cell conditioned medium (SCCM), which previous research has shown to support the re-growth of neuronal cells, the Oxford inventors have now identified a factor that is responsible for stimulation of neuronal re-growth and have demonstrated its effectiveness for both peripheral and central nervous system neurons. Use of this factor or its analogues may provide the basis for a reparative treatment for brain and spinal cord injury.
Jennifer Johnson | alfa
OHIO professor Hla develops robust molecular propeller for unidirectional rotations
22.08.2019 | Ohio University
In cystic fibrosis, lungs feed deadly bacteria
22.08.2019 | Columbia University Irving Medical Center
Theoretical physicists at Trinity College Dublin are among an international collaboration that has built the world's smallest engine - which, as a single calcium ion, is approximately ten billion times smaller than a car engine.
Work performed by Professor John Goold's QuSys group in Trinity's School of Physics describes the science behind this tiny motor.
Together with the University of Innsbruck, the ETH Zurich and Interactive Fully Electrical Vehicles SRL, Infineon Austria is researching specific questions on the commercial use of quantum computers. With new innovations in design and manufacturing, the partners from universities and industry want to develop affordable components for quantum computers.
Ion traps have proven to be a very successful technology for the control and manipulation of quantum particles. Today, they form the heart of the first...
Experimental progress towards engineering quantized gauge fields coupled to ultracold matter promises a versatile platform to tackle problems ranging from condensed-matter to high-energy physics
The interaction between fields and matter is a recurring theme throughout physics. Classical cases such as the trajectories of one celestial body moving in the...
Soft robots have a distinct advantage over their rigid forebears: they can adapt to complex environments, handle fragile objects and interact safely with humans. Made from silicone, rubber or other stretchable polymers, they are ideal for use in rehabilitation exoskeletons and robotic clothing. Soft bio-inspired robots could one day be deployed to explore remote or dangerous environments.
Most soft robots are actuated by rigid, noisy pumps that push fluids into the machines' moving parts. Because they are connected to these bulky pumps by tubes,...
Researchers at TU Graz are working together with European partners on new possibilities of measuring vehicle emissions.
Today, air pollution is one of the biggest challenges facing European cities. As part of the Horizon 2020 research project CARES (City Air Remote Emission...
16.08.2019 | Event News
14.08.2019 | Event News
12.08.2019 | Event News
22.08.2019 | Life Sciences
22.08.2019 | Physics and Astronomy
22.08.2019 | Physics and Astronomy