Researchers in Oxford University’s Department of Human Anatomy have identified a factor involved in the regeneration of neurons in the central nervous system. The discovery and use of this factor could provide the basis for a reparative treatment for both brain and spinal cord injuries.
Unlike lower vertebrates, mammals have lost the ability to repair damage to the brain and spinal cord. Since peripheral nerves are capable of repair, this is thought to be not so much an intrinsic inability of central nervous system (CNS) tissue to repair itself, but rather an environment in the CNS that is hostile to regeneration. This inhibition of neuronal regeneration is a result of a number of factors including axotomy-induced cell death, a gliotic scar that provides a physical barrier to regeneration as well as an environment that is inhibitory to growth. A number of strategies have been employed in the past to overcome this inhibition, including: blocking apoptosis, stem cell therapy, grafting of peripheral nervous system (PNS) cells and delivery of neurotrophic factors. However, the results of these animal studies have been controversial with regard to their claims of significant functional recovery.
Following a great deal of work on the action of Schwann cell conditioned medium (SCCM), which previous research has shown to support the re-growth of neuronal cells, the Oxford inventors have now identified a factor that is responsible for stimulation of neuronal re-growth and have demonstrated its effectiveness for both peripheral and central nervous system neurons. Use of this factor or its analogues may provide the basis for a reparative treatment for brain and spinal cord injury.
Jennifer Johnson | alfa
Scientists uncover the role of a protein in production & survival of myelin-forming cells
19.07.2018 | Advanced Science Research Center, GC/CUNY
NYSCF researchers develop novel bioengineering technique for personalized bone grafts
18.07.2018 | New York Stem Cell Foundation
A new manufacturing technique uses a process similar to newspaper printing to form smoother and more flexible metals for making ultrafast electronic devices.
The low-cost process, developed by Purdue University researchers, combines tools already used in industry for manufacturing metals on a large scale, but uses...
For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...
Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...
Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
13.07.2018 | Event News
12.07.2018 | Event News
03.07.2018 | Event News
20.07.2018 | Power and Electrical Engineering
20.07.2018 | Information Technology
20.07.2018 | Materials Sciences