In a new study published in the April 1, 2003 issue of Genes and Development, scientists at University Health Network’s Advanced Medical Discovery Institute (AMDI)/Ontario Cancer Institute (OCI) have shown that a molecule called caspase-8 plays a key role in the immune system response, by controlling how T-cells are activated to respond to infections.
T-cells are white blood cells that recognize and fight off viruses and bacteria. When T-cells encounter these foreign invaders they build up a T-cell "army" by multiplying themselves many thousand-fold in process known as activation. Once their job is complete, T-cells are eliminated in a process known as apoptosis. While caspase-8 is largely recognized as a critical factor in this elimination process, this study produced a new finding: caspase-8 is also essential for the activation of T-cells at the start of the immune response.
"This research has helped us better understand how caspase-8 activates the immune system response by triggering T-cells to proliferate. When caspase-8 is inhibited, the immune response is significantly decreased," explains Dr. Razqallah Hakem, principal investigator AMDI/OCI and Assistant Professor in Medical Biophysics at the University of Toronto.
Kim Garwood | University of Toronto
New eDNA technology used to quickly assess coral reefs
18.04.2019 | University of Hawaii at Manoa
New automated biological-sample analysis systems to accelerate disease detection
18.04.2019 | Polytechnique Montréal
A stellar flare 10 times more powerful than anything seen on our sun has burst from an ultracool star almost the same size as Jupiter
A localization phenomenon boosts the accuracy of solving quantum many-body problems with quantum computers which are otherwise challenging for conventional computers. This brings such digital quantum simulation within reach on quantum devices available today.
Quantum computers promise to solve certain computational problems exponentially faster than any classical machine. “A particularly promising application is the...
The technology could revolutionize how information travels through data centers and artificial intelligence networks
Engineers at the University of California, Berkeley have built a new photonic switch that can control the direction of light passing through optical fibers...
Physicists observe how electron-hole pairs drift apart at ultrafast speed, but still remain strongly bound.
Modern electronics relies on ultrafast charge motion on ever shorter length scales. Physicists from Regensburg and Gothenburg have now succeeded in resolving a...
Engineers create novel optical devices, including a moth eye-inspired omnidirectional microwave antenna
A team of engineers at Tufts University has developed a series of 3D printed metamaterials with unique microwave or optical properties that go beyond what is...
17.04.2019 | Event News
15.04.2019 | Event News
09.04.2019 | Event News
18.04.2019 | Life Sciences
18.04.2019 | Physics and Astronomy
18.04.2019 | Life Sciences