In this Johns Hopkins engineering lab, Gurkan Guntas and Marc Ostermeier used a technique called domain insertion to join two proteins and create a molecular switch.
Photo by Will Kirk
Technique could lead to new drug delivery systems, biological warfare sensors
Using a lab technique called domain insertion, Johns Hopkins researchers have joined two proteins in a way that creates a molecular “switch.” The result, the researchers say, is a microscopic protein partnership in which one member controls the activity of the other. Similarly coupled proteins may someday be used to produce specialized molecules that deliver lethal drugs only to cancerous cells. They also might be used to set off a warning signal when biological warfare agents are present.
The technique used to produce this molecular switch was reported March 27 in New Orleans at the 225th national meeting of the American Chemical Society,
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