A recently discovered enzyme called endothelial lipase regulates the structure, metabolism and blood concentration of high density lipoprotein (HDL), the so-called "good cholesterol," said researchers from Baylor College of Medicine in a report in the online version of the Proceedings of the National Academy of Sciences.
In a series of studies in mice, Dr. Lawrence Chan, chief of the section of endocrinology and metabolism at Baylor, his co-workers and colleagues from the section of cardiology and atherosclerosis have found that when mice lack this enzyme, the particles of HDL in their blood are much larger than normal.
"We dont know if it is good or bad that the HDL becomes larger," said Chan. "We were always taught that high levels of HDL are good for you because HDL carries cholesterol from the outer areas of the body back to the liver where it is excreted as bile."
Anissa Anderson Orr | EurekAlert!
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