In an unexpected discovery, a team led by Northwestern University scientists has become the first to show that progesterone, a hormone usually associated with female reproduction and maternal behavior, plays a key role in regulating male aggression toward infants in mice. Testosterone, not progesterone, had been thought to be responsible.
The researchers found that the absence of progesterones actions reduced aggression while promoting positive paternal behavior. The findings, to be published online by the Proceedings of the National Academy of Sciences during the week of Feb. 24, suggest a new approach to studying an area of biology that has been poorly understood.
"We discovered that the hormone progesterone and its receptor are important in males, not just females," said Jon E. Levine, professor of neurobiology and physiology, who led the provocative study. "Paternal behavior may be based in the same biology as maternal behavior."
Megan Fellman | EurekAlert!
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