Important goal achieved in potential animal-to-human organ transplantation
In a session today at the annual meeting of the International Embryo Transfer Society (IETS), Randall Prather, Ph.D., Distinguished Professor of Reproductive Biotechnology at the University of Missouri-Columbia, announced the successful cloning of the first miniature swine with both copies of a specific gene "knocked out" of its DNA. The ultimate goal of this research, which is being conducted in partnership with Immerge BioTherapeutics, Inc (a BioTransplant Incorporated (Nasdaq:BTRN)/Novartis Pharma AG (NYSE:NYS) joint venture company), is to develop a herd of miniature swine that can be used as a safe source for human transplantation, a process known as xenotransplantation.
"The fact that we have been able to clone this particular strain of miniature swine with both copies of the gene that produces GGTA1 knocked out is a very exciting step for the field of xenotransplantation," said Dr. Prather, a researcher in MUs College of Agriculture, Food and Natural Resources. "Organs from regular swine are too large for human transplant, and this particular strain of miniature swine has been refined for years solely for its potential use in humans."
Susan Hayes | EurekAlert!
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