University of Minnesota researchers, with collaborators at the U. S. Department of Agricultures National Animal Disease Center in Ames, Iowa, have completed sequencing the genome of the bacteria that causes Johnes disease, a major chronic wasting disease found in dairy cattle. The bacterium, Mycobacterium paratuberculosis, is considered one of the most important threats to the health of dairy cattle worldwide and may represent a potential risk to the safety of the milk supply. The gene sequencing will allow researchers to develop new ways of early diagnosis, prevention and treatment of a disease that costs the dairy industry more than $200 million a year. The results of the sequencing analysis are available online at www.pathogenoics.umn.edu, and more about Johnes disease can be found at www.johnes.org.
"This is a horrible, hard to diagnose disease, largely because we lacked an understanding of the basic genetic makeup of the organism and the tools to differentiate the bacterium from other closely related species," said principal investigator Vivek Kapur, Ph.D., a faculty member in the University of Minnesota Medical School and College of Veterinary Medicine, director of the universitys Advanced Genetic Analysis Center and co-director of the Biomedical Genomics Center. "The genome sequence sheds new light on the genes and biochemical pathways in the bacterium, and the research offers a starting point for defining the mechanisms by which the organism causes disease and helping devise new strategies to detect infected animals and ultimately help control the spread of the organism."
M. paratuberculosis is a slow-growing bacterium that causes a chronic gastrointestinal infection in dairy cattle and other small ruminant species (such as sheep, goat, and deer) and has both serious health and economic consequences to dairy farming worldwide. While the bacterium has been recognized to cause Johnes disease for more than 100 years, methods for satisfactory diagnosis, treatment and prevention are lacking.
Deane Morrison | EurekAlert!
Microscope measures muscle weakness
16.11.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg
Good preparation is half the digestion
16.11.2018 | Max-Planck-Institut für Stoffwechselforschung
Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.
Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...
Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...
Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...
On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure
Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...
09.11.2018 | Event News
06.11.2018 | Event News
23.10.2018 | Event News
16.11.2018 | Health and Medicine
16.11.2018 | Life Sciences
16.11.2018 | Life Sciences