The c-myc gene is commonly activated in a variety of human tumors. As a new report in the October 1 issue of Genes & Development shows, scientists are gaining a better understanding as to why.
Dr. John Cleveland and colleagues at St. Jude Childrens Research Hospital have discovered that c-Myc is essential for tumor development, as it regulates factors necessary for the growth of blood vessels into tumors – lending a new potential target to anti-angiogenic cancer therapies.
The myc family of oncogenes (c-myc, N-myc, and L-myc) function in the control of cell proliferation, differentiation, and tumorigenesis. Although it has long been recognized that c-Mycs positive effect on cell proliferation can contribute to cancer development, scientists have also suspected that c-Myc has additional roles in the progression of malignancy. Dr. Cleveland and colleagues have discovered such a role: c-Myc is essential for tumor angiogenesis.
Heather Cosel | EurekAlert!
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