An international team of scientists led by researchers at The Wistar Institute has combined two different imaging techniques to uncover the molecular-level framework of a common bacteriophage, a virus that infects bacteria. The results, reported in the October issue of Nature Structural Biology, suggest that viruses developed a continuum of progressively more complex architectural strategies to cope with their increasing size as they evolved. An image from the study is featured on the journals cover.
The new findings may open a novel approach to developing therapies for certain difficult-to-treat infections. The bacteriophage studied, called PRD1, infects antibiotic-resistant strains of E. coli bacteria, including strains responsible for tens of thousands of cases of food poisoning in the United States each year. The intimate knowledge of PRD1s structure provided by the current study might help scientists develop a treatment for E. coli infections involving PRD1.
The structural details show that the bacteriophage has similarities to viruses smaller than itself, simple plant and animal viruses whose outer coats are formed from proteins held together by linked "arms." In addition, however, it also uses small "glue" proteins to cement larger proteins together. This feature makes it more like the human adenoviruses, larger and more complex viruses that infect the respiratory tract and cause other diseases. Taken together, these features place the bacteriophage at an intermediate point on the viral evolutionary tree and help illuminate the overall evolutionary path taken by families of viruses.
Franklin Hoke | EurekAlert!
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Making better use of enzymes: a new research project at Jacobs University
19.09.2018 | Jacobs University Bremen gGmbH
Thin-film solar cells made of crystalline silicon are inexpensive and achieve efficiencies of a good 14 percent. However, they could do even better if their shiny surfaces reflected less light. A team led by Prof. Christiane Becker from the Helmholtz-Zentrum Berlin (HZB) has now patented a sophisticated new solution to this problem.
"It is not enough simply to bring more light into the cell," says Christiane Becker. Such surface structures can even ultimately reduce the efficiency by...
A study in the journal Bulletin of Marine Science describes a new, blood-red species of octocoral found in Panama. The species in the genus Thesea was discovered in the threatened low-light reef environment on Hannibal Bank, 60 kilometers off mainland Pacific Panama, by researchers at the Smithsonian Tropical Research Institute in Panama (STRI) and the Centro de Investigación en Ciencias del Mar y Limnología (CIMAR) at the University of Costa Rica.
Scientists established the new species, Thesea dalioi, by comparing its physical traits, such as branch thickness and the bright red colony color, with the...
Scientists have succeeded in observing the first long-distance transfer of information in a magnetic group of materials known as antiferromagnets.
An international team of researchers has mapped Nemo's genome, providing the research community with an invaluable resource to decode the response of fish to...
Graphene is considered a promising candidate for the nanoelectronics of the future. In theory, it should allow clock rates up to a thousand times faster than today’s silicon-based electronics. Scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) and the University of Duisburg-Essen (UDE), in cooperation with the Max Planck Institute for Polymer Research (MPI-P), have now shown for the first time that graphene can actually convert electronic signals with frequencies in the gigahertz range – which correspond to today’s clock rates – extremely efficiently into signals with several times higher frequency. The researchers present their results in the scientific journal “Nature”.
Graphene – an ultrathin material consisting of a single layer of interlinked carbon atoms – is considered a promising candidate for the nanoelectronics of the...
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