Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

What do analytical chemicals do?

18.07.2008
Researchers from Rey Juan Carlos University and the University of Alcalá are developing analytical methodologies to quickly and efficiently evaluate asymmetric epoxidation processes of allyl alcohols.

Several industries, from pharmaceutical and chemical to food and others, require enantiomerically pure compounds for the development of their products. Enantiomers are non superposing specular images of a compound that has chiral properties. Many drugs contain chiral active compounds and in some cases, depending on the particular enantiomer used, the therapeutic effect may vary greatly.

This is the reason it is so important today to develop methods to produce enatiomers in a pure form; and also explains why the asymmetric synthesis procedures that produce only the desired enantiomer by means of a catalyst are now the focus of many investigations. Nevertheless, the great surge in development of this type of processes requires the parallel development of new analytical methods capable of evaluating the results obtained based on yield and enantiometric excess.

In 2001, the American chemist K.B. Sharpless was awarded the noble prize in chemistry for the development of a highly enantioselective process to obtain chiral epoxides from allyl alcohols using chiral titanium tartrate. This process is of great significance, since epoxides are widely used in organic synthesis processes as they are useful and versatile molecules that can suffer a large number of transformations due to their high reactivity. Examples can be found in ß-blockers, like Propranolol and for the synthesis of hepatitis B virus inhibitors.

... more about:
»Chiral »analytical »methods

The importance of these compounds and the constant research for new catalytic systems justify the need for the development of analytical methods that allow a simple, quick and efficient evaluation of these processes. For this reason, a research group at the Department of Inorganic and Analytical Chemistry at the Rey Juan Carlos University formed by the Doctors. S. Morante-Zarcero, I. del Hierro, M. Fajardo & I. Sierra, has developed and validated different analytical methods for the determination of such compounds by means of high efficiency liquid chromatography with ultraviolet detection and mass spectrometry (HPLC-DAD and HPLC-MS). Furthermore, in the last few years capillary electrophoresis (CE) has proved its great potential to carry out chiral separations. Thanks to its high efficiency, low reactive consumption and versatility, Professor. Mª Luisa Marina, in collaboration with Dr. Antonio Crego from the Department of Analytical Chemistry at the Alcalá University, applied this technique to develop the first methods using CE to determine chiral epoxides in this type of samples.

All the methodologies that were developed, and that have proven to have good characterising attributes, like linearity, precision, selectivity, detection limit, and quantification, have been used to successfully evaluate asymmetric epoxidation processes of allyl alcohols, using new chiral catalyst compounds based on titanium and have been published in analytical chemistry magazines such as the Journal of Chromatography A, Analytica Chimica Acta and Electrophoresis.

Oficina Información Científica | alfa
Further information:
http://www.madrimasd.org

Further reports about: Chiral analytical methods

More articles from Life Sciences:

nachricht The hidden structure of the periodic system
17.06.2019 | Max-Planck-Institut für Mathematik in den Naturwissenschaften (MPIMIS)

nachricht Tiny probe that senses deep in the lung set to shed light on disease
17.06.2019 | University of Edinburgh

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: The hidden structure of the periodic system

The well-known representation of chemical elements is just one example of how objects can be arranged and classified

The periodic table of elements that most chemistry books depict is only one special case. This tabular overview of the chemical elements, which goes back to...

Im Focus: MPSD team discovers light-induced ferroelectricity in strontium titanate

Light can be used not only to measure materials’ properties, but also to change them. Especially interesting are those cases in which the function of a material can be modified, such as its ability to conduct electricity or to store information in its magnetic state. A team led by Andrea Cavalleri from the Max Planck Institute for the Structure and Dynamics of Matter in Hamburg used terahertz frequency light pulses to transform a non-ferroelectric material into a ferroelectric one.

Ferroelectricity is a state in which the constituent lattice “looks” in one specific direction, forming a macroscopic electrical polarisation. The ability to...

Im Focus: Determining the Earth’s gravity field more accurately than ever before

Researchers at TU Graz calculate the most accurate gravity field determination of the Earth using 1.16 billion satellite measurements. This yields valuable knowledge for climate research.

The Earth’s gravity fluctuates from place to place. Geodesists use this phenomenon to observe geodynamic and climatological processes. Using...

Im Focus: Tube anemone has the largest animal mitochondrial genome ever sequenced

Discovery by Brazilian and US researchers could change the classification of two species, which appear more akin to jellyfish than was thought.

The tube anemone Isarachnanthus nocturnus is only 15 cm long but has the largest mitochondrial genome of any animal sequenced to date, with 80,923 base pairs....

Im Focus: Tiny light box opens new doors into the nanoworld

Researchers at Chalmers University of Technology, Sweden, have discovered a completely new way of capturing, amplifying and linking light to matter at the nanolevel. Using a tiny box, built from stacked atomically thin material, they have succeeded in creating a type of feedback loop in which light and matter become one. The discovery, which was recently published in Nature Nanotechnology, opens up new possibilities in the world of nanophotonics.

Photonics is concerned with various means of using light. Fibre-optic communication is an example of photonics, as is the technology behind photodetectors and...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

SEMANTiCS 2019 brings together industry leaders and data scientists in Karlsruhe

29.04.2019 | Event News

Revered mathematicians and computer scientists converge with 200 young researchers in Heidelberg!

17.04.2019 | Event News

First dust conference in the Central Asian part of the earth’s dust belt

15.04.2019 | Event News

 
Latest News

Novel communications architecture for future ultra-high speed wireless networks

17.06.2019 | Information Technology

Climate Change in West Africa

17.06.2019 | Earth Sciences

Robotic fish to replace animal testing

17.06.2019 | Ecology, The Environment and Conservation

VideoLinks
Science & Research
Overview of more VideoLinks >>>