The tumour cells can disseminate into the organism by using the blood or lymphatic stream. Recent data suggest that the site of implantation of secondary foci or metastases is preset by the elaboration of an appropriate microenvironment.
These novel information led to the emerging concept of “premetastatic niche”. In addition, cancer cells must acquire new properties ensuring their mobility and the invasion of various tissues. Cancer stem cells are thought to constitute the proliferative potential of the tumoral mass and could represent the source of cells metastasizing.
The tumour cell-centrered view of the metastatic process is now revisited taking into account the important contribution of the tumor microenvironment consisting of both cellular and non cellular components, in primary tumors as well as in secondary foci.
A new European network, entitled MICROENVIMET, developed within the 7th EU framework is coordinated by Professor Agnès NOEL (Laboratory of Tumour and the Development Biology, GIGA-Cancer research center of the University of Liege, Belgium). This European scientific network entitled “Microenvimet: Understanding and fighting metastasis by modulating the tumour microenvironment through interference with the protease network” (http://www.microenvimet.eu) gathers 8 international partners. It is funded to the amount of 2.999.689 euro for 4 years by the European commission.
The purpose of the project “microenvimet” is to elucidate and understand the early mechanisms of the metastatic dissemination by studying the contribution of tumour microenvironment during various stages of epithelial cancer evolution: the primary tumour growth, the premetastatic phase preceding the dissemination of the cancer cells and the metastatic phase during which the secondary foci develop. It aims at identifying molecular targets contributing to early steps of the tumour progression. The project is focused on the mechanisms underlying the elaboration of a favorable «soil » for the establishment of metastases (“premetastatic niche”).
Its original approach consists in modifying the tumoral microenvironment, interfering with proteases which constitute important regulators of the interactions which are established between tumoral cells and their cellular and molecular microenvironment. This project is based on the exploitation of innovating technological platforms: genomic platform for the analysis of the RNA messengers and the recently identified microRNA, phage library for the development of blocking antibodies against the identified targets, platform of computer-assisted image analysis and transgenesis platform.
Climate Impact Research in Hannover: Small Plants against Large Waves
17.08.2018 | Leibniz Universität Hannover
First transcription atlas of all wheat genes expands prospects for research and cultivation
17.08.2018 | Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung
New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference
Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
17.08.2018 | Event News
08.08.2018 | Event News
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17.08.2018 | Physics and Astronomy
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17.08.2018 | Life Sciences