Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Brain ‘trick’ offers treatment hope for Alzheimer’s

03.07.2008
Scientists in the UK and Canada have made a significant step forward in the search for new drugs to treat Alzheimer’s disease.

An ageing population means that neurodegeneration, such as Alzheimer’s disease, is one of the major health problems in the developed world. But researchers at the University of York and Simon Fraser University in Burnaby, British Columbia, have designed an enzyme inhibitor which could ‘trick’ the brain and so help to halt neurodegeneration.

The research is published in the latest issue of Nature Chemical Biology.

One of the causes of neurodegeneration is a modification to the protein ‘tau’, which helps to maintain the stability of neurones in the brain, causing them to form aggregates termed ‘tangles’.

... more about:
»Alzheimer »Tau »enzyme

These diseases, or ‘tauopathies’ are believed to be caused by a form of the protein tau which has been excessively modified with phosphate.

By studying the chemistry and structure of relevant enzymes, the research teams at York, led by Professor Gideon Davies, and Simon Fraser, led by Professor David Vocadlo, have designed an enzyme inhibitor that prevents the phosphorylation of tau in animal models. They have effectively tricked the brain’s own enzymes into installing a sugar on to tau in place of the detrimental phosphates.

The enzyme inhibitor, termed a ‘thiazoline’, developed by Professor Vocadlo and Professor Davies is not yet a drug, but it is a major breakthrough in finding compounds that cross the blood-brain barrier to elicit beneficial effects that prevent the onset of tauopathies.

Professor Davies, of the Department of Chemistry at York, said: “We hope that the work will evolve into new drugs to treat Alzheimer’s disease, although that is still many years off. The work highlights the synergy of studying the chemistry of enzymes in living cells.”

The York /Simon Fraser collaboration also revealed the first structure of the enzyme responsible for the installation of these protective sugars in a paper in Nature Structural & Molecular Biology earlier this month.

David Garner | alfa
Further information:
http://www.york.ac.uk
http://www.york.ac.uk/admin/presspr/pressreleases/alzheimersresearch.htm

Further reports about: Alzheimer Tau enzyme

More articles from Life Sciences:

nachricht 3D technology lets us look into the distant past
20.05.2019 | Eberhard Karls Universität Tübingen

nachricht Dangerous pathogens use this sophisticated machinery to infect hosts
20.05.2019 | California Institute of Technology

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Self-repairing batteries

UTokyo engineers develop a way to create high-capacity long-life batteries

Engineers at the University of Tokyo continually pioneer new ways to improve battery technology. Professor Atsuo Yamada and his team recently developed a...

Im Focus: Quantum Cloud Computing with Self-Check

With a quantum coprocessor in the cloud, physicists from Innsbruck, Austria, open the door to the simulation of previously unsolvable problems in chemistry, materials research or high-energy physics. The research groups led by Rainer Blatt and Peter Zoller report in the journal Nature how they simulated particle physics phenomena on 20 quantum bits and how the quantum simulator self-verified the result for the first time.

Many scientists are currently working on investigating how quantum advantage can be exploited on hardware already available today. Three years ago, physicists...

Im Focus: Accelerating quantum technologies with materials processing at the atomic scale

'Quantum technologies' utilise the unique phenomena of quantum superposition and entanglement to encode and process information, with potentially profound benefits to a wide range of information technologies from communications to sensing and computing.

However a major challenge in developing these technologies is that the quantum phenomena are very fragile, and only a handful of physical systems have been...

Im Focus: A step towards probabilistic computing

Working group led by physicist Professor Ulrich Nowak at the University of Konstanz, in collaboration with a team of physicists from Johannes Gutenberg University Mainz, demonstrates how skyrmions can be used for the computer concepts of the future

When it comes to performing a calculation destined to arrive at an exact result, humans are hopelessly inferior to the computer. In other areas, humans are...

Im Focus: Recording embryonic development

Scientists develop a molecular recording tool that enables in vivo lineage tracing of embryonic cells

The beginning of new life starts with a fascinating process: A single cell gives rise to progenitor cells that eventually differentiate into the three germ...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

SEMANTiCS 2019 brings together industry leaders and data scientists in Karlsruhe

29.04.2019 | Event News

Revered mathematicians and computer scientists converge with 200 young researchers in Heidelberg!

17.04.2019 | Event News

First dust conference in the Central Asian part of the earth’s dust belt

15.04.2019 | Event News

 
Latest News

Cement as a climate killer: Using industrial residues to produce carbon neutral alternatives

20.05.2019 | Materials Sciences

When bees are freezing

20.05.2019 | Life Sciences

Machine learning speeds modeling of experiments aimed at capturing fusion energy on Earth

20.05.2019 | Power and Electrical Engineering

VideoLinks
Science & Research
Overview of more VideoLinks >>>