Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New design may lead to custom-tailored drugs with no side effects

18.06.2008
In the May issue of the British journal Drug Discovery Today, Sten Ohlson, professor of biotechnology at Kalmar University in Sweden, argues in a debate article how his thoughts and research results surrounding weak or transient interactions between biochemical molecules could revolutionize tomorrow's drugs.

Sten Ohlson has extensive experience of research into so-called transient biomolecular binding. Such binding is short-lived­-the biomolecules touch each other for a brief moment only. Many of the processes in the human body­-in a cell, for instance­-occur with the aid of transient binding.

The discovery and understanding of how important binding can be is now paving the way for an entirely new type of drug that will be both more effective and multicompetent and moreover will be less likely than today's drugs to lead to the development of tolerance in patients.

It is above all in three areas that Professor Sten Ohlson envisions major potential for the new technology: cardiovascular diseases, pain, and neurological disorders.

... more about:
»Ohlson »Sten »binding

Some multicompetent drugs based on transient interaction are already in use today. One of them is regular aspirin, where acetyl salicylic acid transiently binds to many target structures and thereby works both as a pain reliever and an inflammation alleviator.

At present Sten Ohlson is collaborating with drug companies in the search for substances that can prevent blood clots in connection with heart attacks and stroke.

Sten Ohlson's research on the importance of transient molecular bindings in biological systems is revolutionary, but he maintains that its application is predicated upon other researchers' abandoning old, traditional approaches.

"The greatest obstacle at present, I believe, is getting scientists to begin to think transiently. This is an entirely new way of conceptualizing and understanding the fundamental functions of diseases that affect us and how we can cure them," says Sten Ohlson.

Karin Ekebjär | alfa
Further information:
http://www.hik.se

Further reports about: Ohlson Sten binding

More articles from Life Sciences:

nachricht New eDNA technology used to quickly assess coral reefs
18.04.2019 | University of Hawaii at Manoa

nachricht New automated biological-sample analysis systems to accelerate disease detection
18.04.2019 | Polytechnique Montréal

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Explosion on Jupiter-sized star 10 times more powerful than ever seen on our sun

A stellar flare 10 times more powerful than anything seen on our sun has burst from an ultracool star almost the same size as Jupiter

  • Coolest and smallest star to produce a superflare found
  • Star is a tenth of the radius of our Sun
  • Researchers led by University of Warwick could only see...

Im Focus: Quantum simulation more stable than expected

A localization phenomenon boosts the accuracy of solving quantum many-body problems with quantum computers which are otherwise challenging for conventional computers. This brings such digital quantum simulation within reach on quantum devices available today.

Quantum computers promise to solve certain computational problems exponentially faster than any classical machine. “A particularly promising application is the...

Im Focus: Largest, fastest array of microscopic 'traffic cops' for optical communications

The technology could revolutionize how information travels through data centers and artificial intelligence networks

Engineers at the University of California, Berkeley have built a new photonic switch that can control the direction of light passing through optical fibers...

Im Focus: A long-distance relationship in femtoseconds

Physicists observe how electron-hole pairs drift apart at ultrafast speed, but still remain strongly bound.

Modern electronics relies on ultrafast charge motion on ever shorter length scales. Physicists from Regensburg and Gothenburg have now succeeded in resolving a...

Im Focus: Researchers 3D print metamaterials with novel optical properties

Engineers create novel optical devices, including a moth eye-inspired omnidirectional microwave antenna

A team of engineers at Tufts University has developed a series of 3D printed metamaterials with unique microwave or optical properties that go beyond what is...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Revered mathematicians and computer scientists converge with 200 young researchers in Heidelberg!

17.04.2019 | Event News

First dust conference in the Central Asian part of the earth’s dust belt

15.04.2019 | Event News

Fraunhofer FHR at the IEEE Radar Conference 2019 in Boston, USA

09.04.2019 | Event News

 
Latest News

New automated biological-sample analysis systems to accelerate disease detection

18.04.2019 | Life Sciences

Explosion on Jupiter-sized star 10 times more powerful than ever seen on our sun

18.04.2019 | Physics and Astronomy

New eDNA technology used to quickly assess coral reefs

18.04.2019 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>