Until now it is strongly believed that the immune system controls growth of tumors by killing tumor cells. The Tubingen researchers, members of the Comprehensive Cancer Center, now show that immune responses can prevent tumor growth without killing tumor cells.
They used a model of endogenously growing tumors that develop, like many human tumors, because of a defect in normal cell death. The researchers show that the immune system can prevent tumor growth without destroying tumor cells. They show that early treatment of developing tumors arrests tumor development at very early stages through a strictly cytokine mediated mechanism. One of the important players that prevents the outgrowth of malignant tumors is interferon.
The researchers show further a second important aspect: Immune responses can both - either induce tumor dormancy or, unexpectedly, tumor growth. In the absence of either interferon or tumor necrosis factor the immune response converts the from a protective into a tumor promoting immune response.
In conclusion, the paper gives a great hope and new aspects for the development of new tumor vaccines. They show that tumor immune responses can induce tumor dormancy, which means that the immune response arrests tumors at early stages. Yet, these immune responses have to occur early in tumor development and have to provide the correct pattern of cytokines. In the case of an inappropriate cytokine pattern, i.e. missing interferon or missing tumor necrosis factor, the same response may dramatically enhance tumor growth.Prof. Dr. Martin Röcken, MD
Dr. Ellen Katz | idw
Link between Gut Flora and Multiple Sclerosis Discovered
15.10.2018 | Universität Zürich
Storage & Transport of highly volatile Gases made safer & cheaper by the use of “Kinetic Trapping"
15.10.2018 | Universität Augsburg
Augsburg chemists present a new technology for compressing, storing and transporting highly volatile gases in porous frameworks/New prospects for gas-powered vehicles
Storage of highly volatile gases has always been a major technological challenge, not least for use in the automotive sector, for, for example, methane or...
When we put water in a freezer, water molecules crystallize and form ice. This change from one phase of matter to another is called a phase transition. While this transition, and countless others that occur in nature, typically takes place at the same fixed conditions, such as the freezing point, one can ask how it can be influenced in a controlled way.
We are all familiar with such control of the freezing transition, as it is an essential ingredient in the art of making a sorbet or a slushy. To make a cold...
Thin organic layers provide machines and equipment with new functions. They enable, for example, tiny energy recuperators. In future, these will be installed...
Das Zusammenspiel aus Struktur und Dynamik bestimmt die Funktion von Proteinen, den molekularen Werkzeugen der Zelle. Durch Fortschritte in der...
New measurement method allows researchers to precisely follow the movement of individual molecules over long periods of time
The function of proteins – the molecular tools of the cell – is governed by the interplay of their structure and dynamics. Advances in electron microscopy have...
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01.10.2018 | Event News
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15.10.2018 | Physics and Astronomy
15.10.2018 | Life Sciences
15.10.2018 | Life Sciences