Scientists knew that both these genes were expressed at increased levels as humans and mice age, but their role in the aging process was not clear. Findings by the Mayo team show that p16 provides gas to accelerate cellular aging, while p19 stops that process.
The findings, to be published May 30 in the online issue of Nature Cell Biology, could help explain the development of some characteristics associated with aging, such as loss of muscle mass and strength or cataracts, and how they might be retarded.
“Scientists interested in aging have developed mice that lack p16 or p19, but these mice were not suitable for studies on aging because they all die of cancer before they even begin to age,” says the study’s first author, Darren Baker, a laboratory technician at Mayo Clinic and a doctoral candidate. “By crossing these mice with a mouse strain that ages five times faster than normal due to a mutation in the BubR1 gene, we were able to bypass this problem.”
While other genes are involved in aging, the researchers firmly established that when too much p16 is produced, tissues start to age. Instead of driving aging, the p19 gene was found to counteract the effects of p16. This was completely unexpected, says Jan van Deursen, Ph.D., a molecular biologist at Mayo Clinic, because tissue culture experiments had predicted that p19 expression promotes aging.
Another important finding of the study is that initiation and progression of aging is caused, at least in part, by the accumulation of senescent or aging cells in tissues and organs. These senescent cells have an abnormal gene expression profile and secrete proteins that damage the surrounding cells, affecting tissue and organ function and aspects of aging.
The study was funded by the National Institutes of Health, the Ted Nash Foundation, and the Ellison Medical Foundation.
The study co-authors, all from Mayo Clinic, include Carmen Perez-Terzic, M.D., Ph.D; Fang Jin, M.D.; Kevin Pitel; Nicolas Niederländer, Ph.D.; Karthik Jeganathan; Satsuki Yamada, M.D., Ph.D; Santiago Reyes; Lois Rowe; H. Jay Hiddinga, Ph.D; Norman Eberhardt, Ph.D; and Andre Terzic, M.D., Ph.D.
Robert Nellis | newswise
Microscope measures muscle weakness
16.11.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg
Good preparation is half the digestion
16.11.2018 | Max-Planck-Institut für Stoffwechselforschung
Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.
Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...
Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...
Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...
On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure
Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...
09.11.2018 | Event News
06.11.2018 | Event News
23.10.2018 | Event News
16.11.2018 | Health and Medicine
16.11.2018 | Life Sciences
16.11.2018 | Life Sciences