The WikiProfessional technology underlying the site has been developed based upon the collaborative Wikipedia approach. Described in BioMed Central’s open access journal Genome Biology, WikiProteins provides a method for community annotation on a huge scale.
The article is written by Barend Mons of the Erasmus Medical Center in Rotterdam, and the Leiden University Medical Center, The Netherlands, and his co-authors from Brazil, The Netherlands, Switzerland, the UK and the USA. They include Amos Bairoch of UniProt, Michael Ashburner of GO and Jimmy Wales, the founder of Wikipedia.
The source material for WikiProteins comes from a mixture of existing authoritative databases (such as the Unified Medical Language System, UniProtKB/Swiss-Prot, IntAct and GO), supplemented by concepts mined from scientific papers published in public literature databases. The automated data mining identifies ‘facts’ in these available resources, such as protein functions or protein-disease relationships. This process created over one million biomedical concept clouds – called ‘Knowlets’ – around each individual concept. The developers of the site now hope that many researchers will follow their call to annotate, via WikiProteins, the Knowlets for which they are leading experts. The method enables researchers to add data even from sources that are not openly available, such as from journals only accessible via publishers’ databases, immensely enhancing the potential for comprehensive coverage. Each page of text called up via the system is automatically indexed and concepts are connected to the WikiSpace, so that their definition comes up and the information can be edited directly from the page.
The resulting data in the Wiki is fully and freely accessible to the public, and entries can be annotated by any registered user. Mons said: “We here call on a million minds to annotate a million concepts and collect new facts from full-text literature with the immediate reward of collaborative knowledge discovery and recognition of Wiki-contributions to the scientific community.”
Launched in 2001, Wikipedia is a freely available, collaboratively created online encyclopedia. WikiProteins maps to Wikipedia and has been created as part of the WikiProfessional initiative and there are plans to add new workspaces such as WikiPeople (an intellectual networking environment), and WikiChemicals for other communities.
A preview of the WikiProtein technology is available at http://conceptweblinker.wikiprofessional.org/default.py?url=nph-proxy.cgi/010000A/http/genomebiology.wikiprofessional.org/monsarticle.htm
Happy hour for time-resolved crystallography
17.09.2019 | Max-Planck-Institut für Struktur und Dynamik der Materie
Too much of a good thing: overactive immune cells trigger inflammation
16.09.2019 | Universität Basel
Researchers from the Department of Atomically Resolved Dynamics of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg, the University of Hamburg and the European Molecular Biology Laboratory (EMBL) outstation in the city have developed a new method to watch biomolecules at work. This method dramatically simplifies starting enzymatic reactions by mixing a cocktail of small amounts of liquids with protein crystals. Determination of the protein structures at different times after mixing can be assembled into a time-lapse sequence that shows the molecular foundations of biology.
The functions of biomolecules are determined by their motions and structural changes. Yet it is a formidable challenge to understand these dynamic motions.
At the International Symposium on Automotive Lighting 2019 (ISAL) in Darmstadt from September 23 to 25, 2019, the Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, a provider of research and development services in the field of organic electronics, will present OLED light strips of any length with additional functionalities for the first time at booth no. 37.
Almost everyone is familiar with light strips for interior design. LED strips are available by the metre in DIY stores around the corner and are just as often...
Later during this century, around 2060, a paradigm shift in global energy consumption is expected: we will spend more energy for cooling than for heating....
Researchers from the Department of Atomically Resolved Dynamics of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg, the University of Potsdam (both in Germany) and the University of Toronto (Canada) have pieced together a detailed time-lapse movie revealing all the major steps during the catalytic cycle of an enzyme. Surprisingly, the communication between the protein units is accomplished via a water-network akin to a string telephone. This communication is aligned with a ‘breathing’ motion, that is the expansion and contraction of the protein.
This time-lapse sequence of structures reveals dynamic motions as a fundamental element in the molecular foundations of biology.
Two research teams have succeeded simultaneously in measuring the long-sought Thorium nuclear transition, which enables extremely precise nuclear clocks. TU Wien (Vienna) is part of both teams.
If you want to build the most accurate clock in the world, you need something that "ticks" very fast and extremely precise. In an atomic clock, electrons are...
10.09.2019 | Event News
04.09.2019 | Event News
29.08.2019 | Event News
17.09.2019 | Materials Sciences
17.09.2019 | Health and Medicine
17.09.2019 | Ecology, The Environment and Conservation