Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Tracing biobanks: EU researchers propose identifying DNA collections similar to books

23.05.2008
In a paper published in the Journal of the American Medical Associations (JAMA) this week, European scientists propose applying a structured numeric identifier to studies involving human biological samples collected for DNA. This would allow optimised use of biological resources through increased traceability and open new perspectives for genetics studies.

Tracing biological collections, or biobanks, is crucial for genetic studies of all diseases, since using larger and larger collections is becoming the gold standard of new genetics study designs. Networking between research teams is essential but also raises numerous ethical issues for the scientists who collect and analyse the samples, as well as for the individuals who take part in clinical trials.

In their publication, scientists from several EU projects, including GA²LEN, propose a new identification system that could be applied to all studies, based on the model of the International Standard Book Number (ISBN) which has been used for books for more than forty years. Each study would receive a modular number with a universal structure, to be registered at the time of ethical approval. Such a number could be applied retroactively to existing studies and collections.

The number would have a variable length and would include elements needed to identify the study: a number for the country, a number for the name of the institution acting as custodian to the collection and a number for the collection itself. This system is transparent but also flexible: elements of a study could be identified as well, for example the various surveys in a longitudinal study. Each collection will receive its unique “identity card” that can be referenced in any study using the collection.

... more about:
»Biobank »Genetic »propose

The immediate advantages of a universal number would be to accelerate and stimulate exchanges between scientists, and potentially increase the size of data collections which were analysed for a given research question. The reference number would optimise the literature search and reviews. Moreover, it would allow scientists to link studies with their samples, the methods used, the results, and various scientific publications.

Genome Wide Associations (GWA) studies or meta-analyses often include data of large biobanks studies. A universal number would facilitate this process and enable the next step: to find, trace and include data of smaller studies with better characterised phenotypes and environments in the large studies. This could also include studies from other medical disciplines or collections initially gathered to study other diseases. Critical mass would be reached for statistical analysis without losing details of the disease characterisation.

Finally, this simple system could benefit all actors involved in the human biobank. Scientists could be identified in relation to a study and given credit for their methods and results in future studies using their collections Institutes who funded the study and/or who are custodian of the collection could be identified from the numeric identifier. Individuals and patients involved in the study with their informed consent would be given transparent access to the way the collection they contributed to has been used, while anonymity is preserved.

The proposal was discussed within the several EU-funded projects that supported the work, including GA²LEN, the Global Allergy and Asthma European Network, Genetic Work Package, and three projects focusing on biobanks and/or genetic databases: PHOEBE, Promoting Harmonization of Epidemiological Biobanks, GEN2PHEN, Genotype-to-Phenotype Databases and newly launched BBMRI, a Pan-European Biobanking and Biomolecular Resources Research infrastructure.

Noélie Auvergne | alfa
Further information:
http://www.ga2len.net
http://www.gen2phen.org

Further reports about: Biobank Genetic propose

More articles from Life Sciences:

nachricht Climate Impact Research in Hannover: Small Plants against Large Waves
17.08.2018 | Leibniz Universität Hannover

nachricht First transcription atlas of all wheat genes expands prospects for research and cultivation
17.08.2018 | Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Color effects from transparent 3D-printed nanostructures

New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference

Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

Im Focus: The “TRiC” to folding actin

Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.

Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

LaserForum 2018 deals with 3D production of components

17.08.2018 | Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

 
Latest News

Smallest transistor worldwide switches current with a single atom in solid electrolyte

17.08.2018 | Physics and Astronomy

Robots as Tools and Partners in Rehabilitation

17.08.2018 | Information Technology

Climate Impact Research in Hannover: Small Plants against Large Waves

17.08.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>