Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New Biological Classification of Ovarian Cancer – A Possibility for Better Survival

23.05.2008
A thesis from The Sahlgrenska Academy in Sweden shows that it might be possible to predict with great probability which women with ovarian cancer will survive the disease before painful treatment with antineoplastic agents. A better prognosis would considerably improve the quality of life of patients since the treatment could be made more effective and thereby result in fewer side effects.

”By looking at biological events we have found differences that in future could be used as markers to make a more secure prognosis for women with ovarian cancer”, says biologist Karolina Partheen, who has written the thesis.

Ovarian cancer is an unusual disease in Sweden. But despite few persons being afflicted by it, it is the fifth most common cause of women dying of cancer in our country. When tumors are discovered there are a number of factors that influence what type of treatment the patient will undergo. Patients with a similar prognosis can have completely different experiences. This is a big problem within cancer care today, in the treatment of ovarian cancer and in the treatment of other forms of cancer too. The majority of patients undergo insufficient treatment resulting in serious side effects, which represents a big cost for both patients and healthcare.

”In the long run only half of all patients with ovarian cancer respond to the medication they are subjected to. What causes the difference in the way patients respond to antineoplastic agents is not completely clear today, but an underlying cause could be that the tumors have different biological characteristics”, says Karolina Partheen.

... more about:
»Partheen »Protein »ovarian »prognosis »thesis »tumors

Cancer is caused by something changing in our gene pool, our genes, which make the body’s own cells start dividing uncontrollably. Genes are copied to mRNA that later function as templates from which proteins can be built in a cell. Certain proteins speed up the cell’s division time, while others put the brakes on it. So if there is too much or too little of some protein, or if it becomes wrongly constructed, this can lead to cancer.

In her thesis, Karolina Partheen has measured gene copies and how much mRNA or protein has built in different tumors that have the same prognosis. This is done in order to then compare whether there are any differences between tumors from patients who survive or die from the disease.

”One of the most interesting discoveries in the thesis was a profile that seems to be able to distinguish a particular group of patients where everyone survives. In future, if these patients can be detected before treatment with antineoplastic agents, they would be able to get an alternative treatment that results in fewer side effects. Patients that do not correspond to our profile can receive standard treatment with some further medication from the start and tighter follow-ups. In this way the treatment becomes more effective, and side effects are minimised, as well as costs reduced for any over-treatment of patients”, says Karolina Partheen.

Ulrika Lundin | alfa
Further information:
http://hdl.handle.net/2077/10126
http://www.sahlgrenska.gu.se

Further reports about: Partheen Protein ovarian prognosis thesis tumors

More articles from Life Sciences:

nachricht The hidden structure of the periodic system
17.06.2019 | Max-Planck-Institut für Mathematik in den Naturwissenschaften (MPIMIS)

nachricht Tiny probe that senses deep in the lung set to shed light on disease
17.06.2019 | University of Edinburgh

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: The hidden structure of the periodic system

The well-known representation of chemical elements is just one example of how objects can be arranged and classified

The periodic table of elements that most chemistry books depict is only one special case. This tabular overview of the chemical elements, which goes back to...

Im Focus: MPSD team discovers light-induced ferroelectricity in strontium titanate

Light can be used not only to measure materials’ properties, but also to change them. Especially interesting are those cases in which the function of a material can be modified, such as its ability to conduct electricity or to store information in its magnetic state. A team led by Andrea Cavalleri from the Max Planck Institute for the Structure and Dynamics of Matter in Hamburg used terahertz frequency light pulses to transform a non-ferroelectric material into a ferroelectric one.

Ferroelectricity is a state in which the constituent lattice “looks” in one specific direction, forming a macroscopic electrical polarisation. The ability to...

Im Focus: Determining the Earth’s gravity field more accurately than ever before

Researchers at TU Graz calculate the most accurate gravity field determination of the Earth using 1.16 billion satellite measurements. This yields valuable knowledge for climate research.

The Earth’s gravity fluctuates from place to place. Geodesists use this phenomenon to observe geodynamic and climatological processes. Using...

Im Focus: Tube anemone has the largest animal mitochondrial genome ever sequenced

Discovery by Brazilian and US researchers could change the classification of two species, which appear more akin to jellyfish than was thought.

The tube anemone Isarachnanthus nocturnus is only 15 cm long but has the largest mitochondrial genome of any animal sequenced to date, with 80,923 base pairs....

Im Focus: Tiny light box opens new doors into the nanoworld

Researchers at Chalmers University of Technology, Sweden, have discovered a completely new way of capturing, amplifying and linking light to matter at the nanolevel. Using a tiny box, built from stacked atomically thin material, they have succeeded in creating a type of feedback loop in which light and matter become one. The discovery, which was recently published in Nature Nanotechnology, opens up new possibilities in the world of nanophotonics.

Photonics is concerned with various means of using light. Fibre-optic communication is an example of photonics, as is the technology behind photodetectors and...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

SEMANTiCS 2019 brings together industry leaders and data scientists in Karlsruhe

29.04.2019 | Event News

Revered mathematicians and computer scientists converge with 200 young researchers in Heidelberg!

17.04.2019 | Event News

First dust conference in the Central Asian part of the earth’s dust belt

15.04.2019 | Event News

 
Latest News

Novel communications architecture for future ultra-high speed wireless networks

17.06.2019 | Information Technology

Climate Change in West Africa

17.06.2019 | Earth Sciences

Robotic fish to replace animal testing

17.06.2019 | Ecology, The Environment and Conservation

VideoLinks
Science & Research
Overview of more VideoLinks >>>