To chart the genes that are involved in the development of leukemia – cancer of white blood cells- researchers Jaap Kool, Anthony Uren and colleagues investigated 10.000 mutations in 500 leukemia. Analysis of the 10.000 mutations resulted in the identification of more than 250 new candidate cancer genes.
The researchers used a technique called ‘retroviral insertional mutagenesis’ in mice. This technique is based on the ability of retroviruses to incorporate their DNA into the genome of host cells. The integrated viral DNA can influence the activity of nearby host genes or disrupt the genetic code of a host gene.
If the affected gene is a cancer gene, the viral integration may give rise to the development of a tumor. Host genes that are mutated by the virus can subsequently be identified using DNA analysis.
Kool and Uren, both employed in the Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital in the research groups of professor Anton Berns and professor Maarten van Lohuizen, and their colleagues were the first to combine ‘retroviral insertional mutagenesis’ with automate ‘high- throughput’ DNA analysis.
This enabled them to identify a far larger number of mutations than comparable studies published to date. Not only did this amount to the identification of more than 250 new candidate cancer genes, it also resulted in the discovery of combinations of cancer genes that collaborate in the development of leukemia.
Frederique Melman | alfa
Hopkins researchers ID neurotransmitter that helps cancers progress
25.04.2019 | Johns Hopkins Medicine
Trigger region found for absence epileptic seizures
25.04.2019 | RIKEN
Flexible, organic and printed electronics conquer everyday life. The forecasts for growth promise increasing markets and opportunities for the industry. In Europe, top institutions and companies are engaged in research and further development of these technologies for tomorrow's markets and applications. However, access by SMEs is difficult. The European project SmartEEs - Smart Emerging Electronics Servicing works on the establishment of a European innovation network, which supports both the access to competences as well as the support of the enterprises with the assumption of innovations and the progress up to the commercialization.
It surrounds us and almost unconsciously accompanies us through everyday life - printed electronics. It starts with smart labels or RFID tags in clothing, we...
The human eye is particularly sensitive to green, but less sensitive to blue and red. Chemists led by Hubert Huppertz at the University of Innsbruck have now developed a new red phosphor whose light is well perceived by the eye. This increases the light yield of white LEDs by around one sixth, which can significantly improve the energy efficiency of lighting systems.
Light emitting diodes or LEDs are only able to produce light of a certain colour. However, white light can be created using different colour mixing processes.
Researchers led by Francesca Ferlaino from the University of Innsbruck and the Austrian Academy of Sciences report in Physical Review X on the observation of supersolid behavior in dipolar quantum gases of erbium and dysprosium. In the dysprosium gas these properties are unprecedentedly long-lived. This sets the stage for future investigations into the nature of this exotic phase of matter.
Supersolidity is a paradoxical state where the matter is both crystallized and superfluid. Predicted 50 years ago, such a counter-intuitive phase, featuring...
A stellar flare 10 times more powerful than anything seen on our sun has burst from an ultracool star almost the same size as Jupiter
A localization phenomenon boosts the accuracy of solving quantum many-body problems with quantum computers which are otherwise challenging for conventional computers. This brings such digital quantum simulation within reach on quantum devices available today.
Quantum computers promise to solve certain computational problems exponentially faster than any classical machine. “A particularly promising application is the...
17.04.2019 | Event News
15.04.2019 | Event News
09.04.2019 | Event News
25.04.2019 | Materials Sciences
25.04.2019 | Earth Sciences
25.04.2019 | Life Sciences