Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Nixing immaturity in red blood cells

06.05.2008
A process of self-digestion called autophagy prompts the maturation of red blood cells.

Without a protein called Nix, the cells would not effectively rid themselves of organelles called mitochondria and consequently become short-lived, leading to anemia, said researchers at Baylor College of Medicine in Houston in a report that appears online today in the journal Nature.

“It’s changed our thinking on autophagy,” said Dr. Jin Wang, assistant professor of immunology at BCM and senior author of the report. During autophagy, the cell forms an envelope or vesicle around components of the cell that need to be degraded and removed. The vesicle then fuses with a cellular component called a lysosome that degrades its contents. The inclusion of components in the cell by autophagy vesicles was generally considered to be nonspecific.

“This is not a random process,” said Wang. “Nix is instructing the cell to get rid of these mitochondria.”

... more about:
»autophagy »blood »mitochondria

Nix accomplishes this task by disrupting the mitochondrial membrane potential (represented by difference in voltage across the inner membrane of the mitochondria. The interior is negative and the outside positive. The difference generates a force that drives the synthesis of ATP, the cell’s energy molecule).

“We think the finding is not limited to the clearance of mitochondria in red blood cells,” said Wang. “When other cells get old or stressed, their organelles may become damaged and need to be cleared by autophagy for quality control. If the cells lack such quality controls, they might have problems that result in aging, cancer and neurodegenerative diseases.”

“It helps get rid of old or damaged mitochondria,” he said. “It is a way to keep the cell functioning without going through programmed cell death (apoptosis).”

“Such specific regulation of autophagy may also be important for cell types in the muscle, brain and pancreas,” said Dr. Min Chen, assistant professor of immunology at BCM and a corresponding author of this work. “The next step is to identify proteins interacting with Nix for mitochondrial quality control by autophagy”. Other factors may also regulate this process in addition to Nix, said Hector Sandoval, a BCM graduate student who is the first author of this paper.

Dipali Pathak | EurekAlert!
Further information:
http://www.bcm.edu

Further reports about: autophagy blood mitochondria

More articles from Life Sciences:

nachricht Many cooks don't spoil the broth: Manifold symbionts prepare their host for any eventuality
14.10.2019 | Max-Planck-Institut für Marine Mikrobiologie

nachricht Diagnostics for everyone
14.10.2019 | Max-Planck-Institut für Kolloid- und Grenzflächenforschung

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel Material for Shipbuilding

A new research project at the TH Mittelhessen focusses on the development of a novel light weight design concept for leisure boats and yachts. Professor Stephan Marzi from the THM Institute of Mechanics and Materials collaborates with Krake Catamarane, which is a shipyard located in Apolda, Thuringia.

The project is set up in an international cooperation with Professor Anders Biel from Karlstad University in Sweden and the Swedish company Lamera from...

Im Focus: Controlling superconducting regions within an exotic metal

Superconductivity has fascinated scientists for many years since it offers the potential to revolutionize current technologies. Materials only become superconductors - meaning that electrons can travel in them with no resistance - at very low temperatures. These days, this unique zero resistance superconductivity is commonly found in a number of technologies, such as magnetic resonance imaging (MRI).

Future technologies, however, will harness the total synchrony of electronic behavior in superconductors - a property called the phase. There is currently a...

Im Focus: How Do the Strongest Magnets in the Universe Form?

How do some neutron stars become the strongest magnets in the Universe? A German-British team of astrophysicists has found a possible answer to the question of how these so-called magnetars form. Researchers from Heidelberg, Garching, and Oxford used large computer simulations to demonstrate how the merger of two stars creates strong magnetic fields. If such stars explode in supernovae, magnetars could result.

How Do the Strongest Magnets in the Universe Form?

Im Focus: Liquifying a rocky exoplanet

A hot, molten Earth would be around 5% larger than its solid counterpart. This is the result of a study led by researchers at the University of Bern. The difference between molten and solid rocky planets is important for the search of Earth-like worlds beyond our Solar System and the understanding of Earth itself.

Rocky exoplanets that are around Earth-size are comparatively small, which makes them incredibly difficult to detect and characterise using telescopes. What...

Im Focus: Axion particle spotted in solid-state crystal

Scientists at the Max Planck Institute for Chemical Physics of Solids in Dresden, Princeton University, the University of Illinois at Urbana-Champaign, and the University of the Chinese Academy of Sciences have spotted a famously elusive particle: The axion – first predicted 42 years ago as an elementary particle in extensions of the standard model of particle physics.

The team found signatures of axion particles composed of Weyl-type electrons (Weyl fermions) in the correlated Weyl semimetal (TaSe₄)₂I. At room temperature,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

International Symposium on Functional Materials for Electrolysis, Fuel Cells and Metal-Air Batteries

02.10.2019 | Event News

NEXUS 2020: Relationships Between Architecture and Mathematics

02.10.2019 | Event News

Optical Technologies: International Symposium „Future Optics“ in Hannover

19.09.2019 | Event News

 
Latest News

How to control friction in topological insulators

14.10.2019 | Physics and Astronomy

The shelf life of pyrite

14.10.2019 | Earth Sciences

Shipment tracking for "fat parcels" in the body

14.10.2019 | Health and Medicine

VideoLinks
Science & Research
Overview of more VideoLinks >>>