A research team has developed the first small molecule that can reversibly activate a key protein involved in balancing sodium levels, paving the way for drugs that can treat low blood pressure and related conditions.
The human epithelial sodium channel (ENaC) controls sodium flow across many tissues such as the lungs, kidneys, and colon, and it is vital to maintaining proper salt balance and blood pressure. Interestingly, while there are available drugs that can block over-active sodium channels, which can help treat hypertension and other disorders, no one has yet found effective ENaC activators.
Now, Bryan Moyer and colleagues managed to identify one, called S3969. In studies with both amphibian and human cells, this molecule could increase sodium flow through normal ENaC and restore function to deficient ENaC.
The sustained yet reversible action of S3969 makes it a good model to build future drugs aimed at improving hypotension, neonatal pulmonary edema (reduced sodium uptake in the lungs can lead to fluid retention), and renal salt wasting disorders.
Nick Zagorski | EurekAlert!
New mechanisms regulating neural stem cells
21.02.2019 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt
A landscape of mammalian development
21.02.2019 | Max-Planck-Institut für molekulare Genetik
Up to now, OLEDs have been used exclusively as a novel lighting technology for use in luminaires and lamps. However, flexible organic technology can offer much more: as an active lighting surface, it can be combined with a wide variety of materials, not just to modify but to revolutionize the functionality and design of countless existing products. To exemplify this, the Fraunhofer FEP together with the company EMDE development of light GmbH will be presenting hybrid flexible OLEDs integrated into textile designs within the EU-funded project PI-SCALE for the first time at LOPEC (March 19-21, 2019 in Munich, Germany) as examples of some of the many possible applications.
The Fraunhofer FEP, a provider of research and development services in the field of organic electronics, has long been involved in the development of...
For the first time, an international team of scientists based in Regensburg, Germany, has recorded the orbitals of single molecules in different charge states in a novel type of microscopy. The research findings are published under the title “Mapping orbital changes upon electron transfer with tunneling microscopy on insulators” in the prestigious journal “Nature”.
The building blocks of matter surrounding us are atoms and molecules. The properties of that matter, however, are often not set by these building blocks...
Scientists at the University of Konstanz identify fierce competition between the human immune system and bacterial pathogens
Cell biologists from the University of Konstanz shed light on a recent evolutionary process in the human immune system and publish their findings in the...
Laser physicists have taken snapshots of carbon molecules C₆₀ showing how they transform in intense infrared light
When carbon molecules C₆₀ are exposed to an intense infrared light, they change their ball-like structure to a more elongated version. This has now been...
The so-called Abelian sandpile model has been studied by scientists for more than 30 years to better understand a physical phenomenon called self-organized...
11.02.2019 | Event News
30.01.2019 | Event News
16.01.2019 | Event News
21.02.2019 | Earth Sciences
21.02.2019 | Trade Fair News
21.02.2019 | Life Sciences