That’s the conclusion of a large body of research being presented today at the annual Society for Endocrinology BES meeting in Harrogate. Aldosterone plays a key role in regulating blood pressure and can affect how susceptible you are to developing hypertension later in life.
Researchers at the Medical Research Council Blood Pressure Unit at the University of Glasgow, led by Prof John Connell, have studied the way in which aldosterone affects blood pressure regulation. Aldosterone is a hormone that is produced by the adrenal glands. It acts on the kidneys to make sure that salt levels in the blood are kept at a safe level. However, it also has important actions to alter heart and blood vessel function. Too much aldosterone increases the risk of stroke and heart failure.
The group found that in older people, higher levels of aldosterone in the bloodstream are associated with high blood pressure, while in young adults, high aldosterone levels indicate you are more likely to subsequently develop hypertension later in life. Individual aldosterone levels are determined by a number of factors. People born with a low birth weight tend to have higher aldosterone levels when they are older. Another important influence is genetics - some people have variants of a gene that controls aldosterone that works more efficiently than others. This means that throughout life, certain individuals will have higher aldosterone levels and are more prone to developing high blood pressure. This also suggests that in the future, we may be able to predict from an early age which individuals are more likely to develop hypertension. Lifestyle modification and new drug treatments might then be targeted specifically at this group of people.
Approximately 1 in 4 people in the UK have hypertension. The higher your blood pressure, the greater your risk of suffering from a heart attack or a stroke. Evidence suggests that aldosterone may be a causal factor in 10% of patients with high blood pressure(1).Researcher Prof John Connell said:
Through our research, we have discovered some of the factors that predispose you to having higher aldosterone levels. We now need to build up a better understanding of how production of aldosterone throughout life is controlled. This could help us to discover how to prevent blood pressure rising with age and also allow us to target new drug treatments for high blood pressure.”
Jennie Evans | alfa
Fish recognize their prey by electric colors
13.11.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn
The dawn of a new era for genebanks - molecular characterisation of an entire genebank collection
13.11.2018 | Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung
Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...
Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...
On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure
Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...
Physicists at ETH Zurich demonstrate how errors that occur during the manipulation of quantum system can be monitored and corrected on the fly
The field of quantum computation has seen tremendous progress in recent years. Bit by bit, quantum devices start to challenge conventional computers, at least...
09.11.2018 | Event News
06.11.2018 | Event News
23.10.2018 | Event News
13.11.2018 | Life Sciences
13.11.2018 | Life Sciences
13.11.2018 | Awards Funding