Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Mitochondria play role in pathogenesis of AD and estrogen-induced neuroprotection

08.04.2008
As the major source of free radicals in cells, mitochondria contribute to the high levels of oxidative stress believed to play a role in the pathogenesis of Alzheimer’s disease.

Now, a new study from the laboratory of Dr. Roberta Brinton, University of Southern California, demonstrates that estrogen reduces this oxidative stress caused by the mitochondria while increasing the ability of the mitochondria to generate energy – important since there is usually an energy deficit in the Alzheimer brain.

The study was presented April 5 at Experimental Biology 2008 in San Diego by Jia Yao, a graduate student in Dr. Brinton’s laboratory. The presentation is part of the scientific program of the American Association of Anatomists (AAA), and Mr. Yao’s presentation is a finalist for the AAA Langman Graduate Studet Platform Presentation Award. He also received an AAA travel award.

Mitochondria, small organelles within the cells, use a process called Oxidative Phosphorylation to generate the vast majority of the adenosine triposphate (ATP) molecules that cells utilize to function properly. If the mitochondria become less efficient with age or disease, they use less up oxygen during this process. This inefficiency produces a double hit against the brain: fewer energy molecules being produced and more free radicals being released, leading to damaging oxidative stress.

Using a combination of biochemical and proteomic (protein) approaches, Dr. Brinton’s research team demonstrated how estrogen acts to regulate mitochondrial function in ways pivotal for protection against Alzheimer’s disease. These include:

an increase of mitochondrial efficiency, enhancing the organelles’ ability to generate energy-laden ATP molecules needed by the brain;

increased expression of key proteins required for ATP generation;

reduction of oxidative stress, protecting neurons from oxidative damage;

prevention of excess apoptosis, or programmed cell death, of neurons of the brain;

and protection of neurons from mitochondrial toxins, which can induce further mitochondrial dysfunction and cell death.

Dr. Brinton and her research team currently are validating the energy-production levels of mitochondria as a biomarker that could detect the presence of Alzheimer’s in the earliest stages, when the neurodegenerative process might be stopped or slowed or therapeutics be more effective. They believe this new information on how estrogen regulates mitochondrial function also sheds light on how to develop a new generation of effective Alzheimer therapeutics. Dr. Brinton currently is developing new, brain specific molecules that promote neurological defense against Alzheimer’s, using similar mechanisms as estrogen, but without estrogen’s negative side effects.

Sylvia Wrobel | EurekAlert!
Further information:
http://www.faseb.org

Further reports about: Alzheimer Estrogen Oxidative mitochondria mitochondrial

More articles from Life Sciences:

nachricht Scientists uncover the role of a protein in production & survival of myelin-forming cells
19.07.2018 | Advanced Science Research Center, GC/CUNY

nachricht NYSCF researchers develop novel bioengineering technique for personalized bone grafts
18.07.2018 | New York Stem Cell Foundation

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Future electronic components to be printed like newspapers

A new manufacturing technique uses a process similar to newspaper printing to form smoother and more flexible metals for making ultrafast electronic devices.

The low-cost process, developed by Purdue University researchers, combines tools already used in industry for manufacturing metals on a large scale, but uses...

Im Focus: First evidence on the source of extragalactic particles

For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.

To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...

Im Focus: Magnetic vortices: Two independent magnetic skyrmion phases discovered in a single material

For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.

Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...

Im Focus: Breaking the bond: To take part or not?

Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.

A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...

Im Focus: New 2D Spectroscopy Methods

Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.

"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Conference on Laser Polishing – LaP: Fine Tuning for Surfaces

12.07.2018 | Event News

11th European Wood-based Panel Symposium 2018: Meeting point for the wood-based materials industry

03.07.2018 | Event News

 
Latest News

A smart safe rechargeable zinc ion battery based on sol-gel transition electrolytes

20.07.2018 | Power and Electrical Engineering

Reversing cause and effect is no trouble for quantum computers

20.07.2018 | Information Technology

Princeton-UPenn research team finds physics treasure hidden in a wallpaper pattern

20.07.2018 | Materials Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>