After several exposures to malaria, humans develop clinical immunity to the disease. In this state, they no longer have symptoms of malaria, but are nevertheless capable of transmitting the disease to others. In regions where malaria is endemic, many people have developed clinical immunity, and this has a large effect on how the disease spreads, that is, on its epidemiology.
Gabriela Gomes and her team at the Theoretical Epidemiology group developed a mathematical model which, for the first time, estimates the significance of asymptomatic infections in malaria transmission when looking at the distribution of the disease in different populations. They applied their model to data from hospital admissions of children with malaria, provided by researchers working in eight different regions in sub-Saharan Africa, where malaria is endemic.
The model shows that, contrary to what was previously thought, in regions of moderate transmission there is a threshold for malaria eradication, separating endemic and malaria-free states. Any intervention success depends critically on reducing occurrence of disease below this threshold, which the model predicts to be possible in areas of moderate transmission, which is the case for most of Africa.
Industrialised nations sit well below this threshold, in the malaria-free state, since the number of clinically immune people is extremely low, making any re-emergence of malaria in these countries highly improbable.
Ricardo Águas, first author of the paper, says, “This is a very powerful model, since it should allow us to determine quantifiable targets for reducing transmission of malaria (by providing mosquito nets, for example) and for fighting the disease (through mass- handing out of anti-malaria drugs), for a specific region.”
Gabriela Gomes added, “Huge efforts are being put into fighting malaria in developing countries. Our model presents a very optimistic outlook for eradicating the disease in areas where it is moderately endemic, contrary to current thinking. We are now looking for research partners who may provide us with more clinical data, from more regions in Africa, which we could use to strengthen our model, and feed into effective eradication programmes.”
Rebecca Walton | alfa
Megakaryocytes act as „bouncers“ restraining cell migration in the bone marrow
16.07.2019 | Rudolf-Virchow-Zentrum für Experimentelle Biomedizin der Universität Würzburg
A human liver cell atlas
15.07.2019 | Max Planck Institute of Immunobiology and Epigenetics
Scientists at the University Würzburg and University Hospital of Würzburg found that megakaryocytes act as “bouncers” and thus modulate bone marrow niche properties and cell migration dynamics. The study was published in July in the Journal “Haematologica”.
Hematopoiesis is the process of forming blood cells, which occurs predominantly in the bone marrow. The bone marrow produces all types of blood cells: red...
For some phenomena in quantum many-body physics several competing theories exist. But which of them describes a quantum phenomenon best? A team of researchers from the Technical University of Munich (TUM) and Harvard University in the United States has now successfully deployed artificial neural networks for image analysis of quantum systems.
Is that a dog or a cat? Such a classification is a prime example of machine learning: artificial neural networks can be trained to analyze images by looking...
An international research group led by scientists from the University of Bayreuth has produced a previously unknown material: Rhenium nitride pernitride. Thanks to combining properties that were previously considered incompatible, it looks set to become highly attractive for technological applications. Indeed, it is a super-hard metallic conductor that can withstand extremely high pressures like a diamond. A process now developed in Bayreuth opens up the possibility of producing rhenium nitride pernitride and other technologically interesting materials in sufficiently large quantity for their properties characterisation. The new findings are presented in "Nature Communications".
The possibility of finding a compound that was metallically conductive, super-hard, and ultra-incompressible was long considered unlikely in science. It was...
An interdisciplinary research team at the Technical University of Munich (TUM) has built platinum nanoparticles for catalysis in fuel cells: The new size-optimized catalysts are twice as good as the best process commercially available today.
Fuel cells may well replace batteries as the power source for electric cars. They consume hydrogen, a gas which could be produced for example using surplus...
The fly agaric with its red hat is perhaps the most evocative of the diverse and variously colored mushroom species. Hitherto, the purpose of these colors was...
24.06.2019 | Event News
29.04.2019 | Event News
17.04.2019 | Event News
16.07.2019 | Physics and Astronomy
16.07.2019 | Power and Electrical Engineering
16.07.2019 | Information Technology