In the widely accepted model of neurogenesis in Drosophila, neuroblasts divide asymmetrically both to self renew and to produce a smaller progenitor cell. This cell then divides into two daughter cells, which receive cell fate determinants, causing them to exit the cell cycle and differentiate.
In mammals, neural stem cells may also divide asymmetrically but can then amplify the number of cells they produce through intermediate progenitors, which divide symmetrically. A research team from the University of Basel, Switzerland set out to study whether specific Drosophila neural stem cells, neuroblasts, might increase the number of cells generated in the larval brain via a similar mechanism.
The team used cell lineage tracing and genetic marker analysis to show that surprisingly large neuroblast lineages are present in the dorsomedial larval brain – a result, they say, of amplified neuroblast proliferation mediated through intermediate progenitors.
In the novel mechanism postulated by the researchers, there are intermediate progenitors present that divide symmetrically in terms of morphology, but asymmetrically in molecular terms. This latter feature means that cell fate determinants are segregated into only one daughter cell, leaving the other free to divide several more times, thus amplifying the number of cells generated.
The authors write: “The surprising similarities in the patterns of neural stem and intermediate progenitor cell division in Drosophila and mammals, suggest that amplification of brain neurogenesis in both groups of animals may rely on evolutionarily conserved cellular and molecular mechanisms.”
Scientists uncover the role of a protein in production & survival of myelin-forming cells
19.07.2018 | Advanced Science Research Center, GC/CUNY
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A new manufacturing technique uses a process similar to newspaper printing to form smoother and more flexible metals for making ultrafast electronic devices.
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To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...
Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...
Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
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