The Uukuniemi virus is the first bunyavirus whose structure researchers have been able to determine. Together with more detailed studies of the viral membrane proteins, knowledge of the Uukuniemi virus may provide a basis for development of drugs for treating bunyavirus diseases, such as hemorrhagic fever and encephalitis.
The findings were published in PNAS on the 12th February, 2008.
The researchers solved the three-dimensional structure of the virus particle, which is only 0.0001 mm in diameter, using electron tomography and computational methods. The newly determined virus structure also serves as a model for the other bunyaviruses. Recent research surprisingly revealed that the viral membrane proteins protruding as spikes from the Uukuniemi virus surface changed their shape in an acidic environment. This phenomenon is reminiscent of the mechanism whereby influenza and dengue viruses enter their host cells. The observation helps to explain how bunyaviruses infect their host cells.
The Uukuniemi virus was first isolated in the village of Uukuniemi, Finland in the early ’60s. Since then, it has proven to be an excellent model virus. Not being a human pathogen, the Uukuniemi virus is safe to work with, and yet it is very similar to many pathogenic bunyaviruses.
The Bunyaviridae viral family comprises more than 300 members and they are found worldwide. Many members of the family cause serious disease, such as hemorrhagic fever and encephalitis, for which no vaccines are available yet. Most of the bunyaviruses are transmitted by mosquitoes and ticks. The exception is hantaviruses, which belong to the Bunyaviridae family, and which are spread by voles and other rodents.
More information: Dr. Juha Huiskonen email@example.com
Kirsikka Mattila | alfa
Microscope measures muscle weakness
16.11.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg
Good preparation is half the digestion
16.11.2018 | Max-Planck-Institut für Stoffwechselforschung
Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.
Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...
Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...
Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...
On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure
Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...
09.11.2018 | Event News
06.11.2018 | Event News
23.10.2018 | Event News
16.11.2018 | Health and Medicine
16.11.2018 | Life Sciences
16.11.2018 | Life Sciences