Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Mouse model shows potential efficacy of HIV prevention strategy

16.01.2008
A new kind of laboratory mouse can be used to test the efficacy of much-needed methods to prevent transmission of HIV, the virus that causes AIDS, according to research by J. Victor Garcia and colleagues at the University of Texas Southwestern Medical Center in Dallas.

The findings, published in PLoS Medicine, demonstrate the utility of such mice for animal testing of pre-exposure antiviral drugs to protect against HIV infection. Such mice also provide a new way of evaluating microbicides and other prevention approaches that have generally required testing in macaques, using viruses that are related, but not identical, to HIV.

Unmodified mice cannot be infected with HIV. Earlier laboratory-modified mice, such as the SCID-hu mouse, contain human thymic tissue that can only become infected after direct injection, but not through any of the natural routes of HIV transmission in humans including the genital route. However, of the 2.5 million newly acquired HIV infections estimated to have occurred in 2007, more than half were in women, mostly through unprotected vaginal sex with an infected male partner.

The new development involves “BLT” mice, which have been transplanted with human blood cells, liver, and thymus tissue. The researchers found that human cells necessary for HIV infection distributed themselves in the female reproductive tract of BLT mice, rendering them susceptible to vaginal infection with HIV. They also found that infection spread to other organs in a way that resembles the course of HIV infection in humans. Finally, they showed that vaginal infection could be blocked by treating the mice with antiretroviral drugs that are currently being evaluated as pre-exposure prophylaxis (PrEP) -- a possible means of HIV prevention in humans at risk for sexual exposure to HIV.

... more about:
»HIV »HIV infection »Prevention »vaginal

These findings support the promising results of PrEP studies from established, but costly, macaque models. Whether the BLT mouse – or any animal model -- provides a reliable predictor of HIV prevention in humans can only be determined by comparison of animal experiments to actual human trials.

The paper is discussed in a related perspective article by Barbara Shacklett (University of California Davis), entitled “Can the New Humanized Mouse Model Give HIV Research a Boost?” At this stage, says Dr Shacklett, “the most prudent approach is to consider the new humanized rodents and the more established, nonhuman primate models as complementary systems, both of which can yield useful information but neither of which is infallible.”

Citation: Denton PW, Estes JD, Sun Z, Othieno FA, Wei BL, et al. (2008) Antiretroviral pre-exposure prophylaxis prevents vaginal transmission of HIV-1 in humanized BLT mice. PLoS Med 5(1) e16.

Josh Eveleth | EurekAlert!
Further information:
http://www.plos.org
http://medicine.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pmed.0050016

Further reports about: HIV HIV infection Prevention vaginal

More articles from Life Sciences:

nachricht Mass spectrometry sheds new light on thallium poisoning cold case
14.12.2018 | University of Maryland

nachricht Protein involved in nematode stress response identified
14.12.2018 | University of Illinois College of Agricultural, Consumer and Environmental Sciences

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Data use draining your battery? Tiny device to speed up memory while also saving power

The more objects we make "smart," from watches to entire buildings, the greater the need for these devices to store and retrieve massive amounts of data quickly without consuming too much power.

Millions of new memory cells could be part of a computer chip and provide that speed and energy savings, thanks to the discovery of a previously unobserved...

Im Focus: An energy-efficient way to stay warm: Sew high-tech heating patches to your clothes

Personal patches could reduce energy waste in buildings, Rutgers-led study says

What if, instead of turning up the thermostat, you could warm up with high-tech, flexible patches sewn into your clothes - while significantly reducing your...

Im Focus: Lethal combination: Drug cocktail turns off the juice to cancer cells

A widely used diabetes medication combined with an antihypertensive drug specifically inhibits tumor growth – this was discovered by researchers from the University of Basel’s Biozentrum two years ago. In a follow-up study, recently published in “Cell Reports”, the scientists report that this drug cocktail induces cancer cell death by switching off their energy supply.

The widely used anti-diabetes drug metformin not only reduces blood sugar but also has an anti-cancer effect. However, the metformin dose commonly used in the...

Im Focus: New Foldable Drone Flies through Narrow Holes in Rescue Missions

A research team from the University of Zurich has developed a new drone that can retract its propeller arms in flight and make itself small to fit through narrow gaps and holes. This is particularly useful when searching for victims of natural disasters.

Inspecting a damaged building after an earthquake or during a fire is exactly the kind of job that human rescuers would like drones to do for them. A flying...

Im Focus: Topological material switched off and on for the first time

Key advance for future topological transistors

Over the last decade, there has been much excitement about the discovery, recognised by the Nobel Prize in Physics only two years ago, that there are two types...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

ICTM Conference 2019: Digitization emerges as an engineering trend for turbomachinery construction

12.12.2018 | Event News

New Plastics Economy Investor Forum - Meeting Point for Innovations

10.12.2018 | Event News

EGU 2019 meeting: Media registration now open

06.12.2018 | Event News

 
Latest News

Data use draining your battery? Tiny device to speed up memory while also saving power

14.12.2018 | Power and Electrical Engineering

Tangled magnetic fields power cosmic particle accelerators

14.12.2018 | Physics and Astronomy

In search of missing worlds, Hubble finds a fast evaporating exoplanet

14.12.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>