Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New means of protection against sepsis

17.12.2007
Scientists from six Scientific-Research Institutes in Puschino, Moscow and St. Petersburg have jointly undertaken a research effort to investigate the HSP70 heat shock protein’s ability to prevent development of septic shock.

Sepsis remains the main death cause in clinics of intensive therapy despite many years of scientists’ continuous research. In the USA and European countries, sepsis develops annually with over 500,000 patients, on top of that the number of confirmed cases is growing by 1.5% every year. Sepsis occurs as a result of the activity of endotoxins, Lipopolysaccharides of bacteria.

Endotoxins stimulate immune system cells, and in the long run this causes hormonal and biochemical dysfunctions of the main bodily organs, in particular, the liver and kidneys. The body tries to protect itself with the help of different means including the heat shock protein. The heat shock protein protects cells and the overall organism against various diseases, including ischemia, inflammation, cancer, as well as metabolic or neurodegenerative diseases. Since that time there have been developed various methods of getting and clearing one of the heat shock proteins - HSP70 - which scientists are currently trying to accommodate for therapeutic purposes. Russian experts have investigated the effect of the HSP70 as the sepsis prevention factor on rats.

The scientists simulated sepsis having injected endotoxins intravenously - Lipopolysaccharide of the Colibacillus, or Salmonella. Ten minutes before or 10 minutes after the endotoxin injection, the rats would be injected the heat shock protein, derived from the bull muscles and thoroughly refined. The reference group rats were injected the physiological solution. The researchers took measurements of the blood biochemical parameters of the laboratory animals, such as glucose and the whole protein concentration, albumin, triglycerides, creatinine and bilirubin tests. The blood tests would be taken in some cases before the injection, in other cases - 20 minutes after and in some other cases - 5 hours after the injection. Before the experiment the scientists had confirmed that the heat shock protein itself did not impact the blood composition, therefore it was harmless.

... more about:
»Endotoxin »Injection »Sepsis »effect »heat

The experiment proved the following: if the heat shock protein is injected 10 minutes before the infection, it produces positive protective effect and stabilizes some of the blood indexes. If the protein is injected after the endotoxin injection, the effect is much weaker. In this case, the protein positively affects values of two blood indexes only: concentration of the whole protein and albumin, and only provided that the Escherichia coli endotoxin was used for the injection.

However, the researchers believe that the discovered heat shock protein’s antiseptic effect is an important factor in terms of possibility to reduce the animal death-rate caused by endotoxins of different origins. They assume that later on this protein can be used to produce a drug or as a preventive protection agent against sepsis in human beings treatment.

Nadezda Markina | alfa
Further information:
http://www.informnauka.ru

Further reports about: Endotoxin Injection Sepsis effect heat

More articles from Life Sciences:

nachricht Cell Division at High Speed
19.06.2019 | Julius-Maximilians-Universität Würzburg

nachricht Monitoring biodiversity with sound: how machines can enrich our knowledge
18.06.2019 | Georg-August-Universität Göttingen

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Successfully Tested in Praxis: Bidirectional Sensor Technology Optimizes Laser Material Deposition

The quality of additively manufactured components depends not only on the manufacturing process, but also on the inline process control. The process control ensures a reliable coating process because it detects deviations from the target geometry immediately. At LASER World of PHOTONICS 2019, the Fraunhofer Institute for Laser Technology ILT will be demonstrating how well bi-directional sensor technology can already be used for Laser Material Deposition (LMD) in combination with commercial optics at booth A2.431.

Fraunhofer ILT has been developing optical sensor technology specifically for production measurement technology for around 10 years. In particular, its »bd-1«...

Im Focus: The hidden structure of the periodic system

The well-known representation of chemical elements is just one example of how objects can be arranged and classified

The periodic table of elements that most chemistry books depict is only one special case. This tabular overview of the chemical elements, which goes back to...

Im Focus: MPSD team discovers light-induced ferroelectricity in strontium titanate

Light can be used not only to measure materials’ properties, but also to change them. Especially interesting are those cases in which the function of a material can be modified, such as its ability to conduct electricity or to store information in its magnetic state. A team led by Andrea Cavalleri from the Max Planck Institute for the Structure and Dynamics of Matter in Hamburg used terahertz frequency light pulses to transform a non-ferroelectric material into a ferroelectric one.

Ferroelectricity is a state in which the constituent lattice “looks” in one specific direction, forming a macroscopic electrical polarisation. The ability to...

Im Focus: Determining the Earth’s gravity field more accurately than ever before

Researchers at TU Graz calculate the most accurate gravity field determination of the Earth using 1.16 billion satellite measurements. This yields valuable knowledge for climate research.

The Earth’s gravity fluctuates from place to place. Geodesists use this phenomenon to observe geodynamic and climatological processes. Using...

Im Focus: Tube anemone has the largest animal mitochondrial genome ever sequenced

Discovery by Brazilian and US researchers could change the classification of two species, which appear more akin to jellyfish than was thought.

The tube anemone Isarachnanthus nocturnus is only 15 cm long but has the largest mitochondrial genome of any animal sequenced to date, with 80,923 base pairs....

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

SEMANTiCS 2019 brings together industry leaders and data scientists in Karlsruhe

29.04.2019 | Event News

Revered mathematicians and computer scientists converge with 200 young researchers in Heidelberg!

17.04.2019 | Event News

First dust conference in the Central Asian part of the earth’s dust belt

15.04.2019 | Event News

 
Latest News

A new force for optical tweezers awakens

19.06.2019 | Physics and Astronomy

New AI system manages road infrastructure via Google Street View

19.06.2019 | Information Technology

A new manufacturing process for aluminum alloys

19.06.2019 | Materials Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>