Scientists at the University of Michigan Heath System and their collaborators have found four new DNA "hotspots" that may one day help guide new treatments for psoriasis, one of the most common autoimmune diseases in the country.
Using cutting-edge methods to peer into the hidden genetic underpinnings of the disabling and disfiguring disease, the research, published in Nature Genetics, further maps the as-yet unknown territories of psoriasis and psoriatic arthritis.
The findings could lead to new drug targets and tailored treatments for the skin disease, says James T. Elder, M.D., Ph.D., the Kirk D. Wuepper Professor of Molecular Genetic Dermatology and lead investigator on the study, which included researchers from the Department of Dermatology and School of Public Health.
"This is a hot topic in genetics these days," Elder says. "Even when you add up all the genes that have been found around the world so far, they only account for about 40 percent of the genetic liability to psoriasis. The question among geneticists continues to be, 'Where is the dark matter?' "
The new research builds on past work by the U-M team, whose discoveries have helped to unveil the hereditary factors of the disease and provide scientists with a better understanding of psoriasis' relationship to other autoimmune diseases, such as Crohn's disease, rheumatoid arthritis and lupus.
So far, research worldwide has linked 25 genes to psoriasis, which has a strong hereditary component. Including the new discoveries, Elder's team was involved in finding more than half of them.
Two of the four new susceptibility loci – or "hotspots" – were strongly linked to psoriatic arthritis, a painful and destructive form of arthritis that affects about 1 in 4 psoriasis patients, Elder says.
The roughly 7.5 million Americans with psoriasis also have a higher risk of dying from related cardiovascular problems.
Once a full catalog of psoriasis genes has been identified, scientists hope to generate a "psoriasis gene profile" that can predict one's risk of developing the disease and pave the way for innovative treatments. Current treatments, including different types of immunosuppressive agents, aren't always effective and can cause serious side effects – though a new drug called Stelara (ustekinumab), which targets one of the genes they discovered, has been giving patients months-long relief, Elder says.
U-M Professor of Biostatistics Goncalo R. Abecasis, D. Phil, was instrumental in designing software and statistical methods to analyze more than 6 million genetic variants from more than 4,000 people.
"It was a pretty daunting task," Abecasis says. "We looked in greater detail at genetic variation than is typical so that we can understand the biology behind psoriasis and build better drugs."
Methodology: The U-M led, multi-center, international study analyzed data from two recent psoriasis genome-wide association studies involving more than 4,300 individuals, with and without the disease. Those findings were followed up in a three-stage replication study involving more than 8,700 people. The newly identified loci include one at NOS2, one at FBXL19, one near PSMA6-NFKBIA, and one near TRAF3IP2. U-M led the research in the discovery of three of the loci. The TRAF3IP2 locus was reported in a second paper to be published in the same issue of Nature Genetics, in which Elder's collaborators from the University of Kiel in Germany took a leading role.
Additional authors: Philip E. Stuart, Rajan P. Nair, Trilokraj Tejasvi, Johann E. Gudjonsson, Jun Ding, Yun Li, Robert Ike, John J. Voorhees, University of Michigan; Eva Ellinghaus, Andre Franke, University of Kiel, Germany; Stephan Weidinger, Bernadette Eberlein, University of Munich, Germany; Christian Gieger, H. Erich Wichmann, Ludwig-Maximilians University, Germany; Manfred Kunz, University of Lübeck, Germany; Gerald G. Krueger, University of Utah; Anne M. Bowcock, Washington University at St. Louis; Ulrich Mrowietz, Michael Weichenthal, University of Kiel, Germany; Henry W. Lim, Henry Ford Hospital, Detroit; Proton Rahman, Memorial University (Canada); Dafna D.Gladman, University of Toronto, Canada.
Funding: The research was supported by grants from the National Institutes of Health, Ann Arbor Veterans Affairs Hospital, German Ministry of Education and Research, and the Canadian Institutes of Health Research.
Disclosure: U-M has filed for patent protection and is actively engaged in finding a commercial partner who can help bring the developments to market.
Reference: Nature Genetics, published online Oct. 17, 2010. Print publication pending.
Resources:Psoriasis Genetics Study at U-M,
Ian Demsky | EurekAlert!
Brought to light – chromobodies reveal changes in endogenous protein concentration in living cells
21.09.2018 | NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen
A one-way street for salt
21.09.2018 | Julius-Maximilians-Universität Würzburg
The building blocks of matter in our universe were formed in the first 10 microseconds of its existence, according to the currently accepted scientific picture. After the Big Bang about 13.7 billion years ago, matter consisted mainly of quarks and gluons, two types of elementary particles whose interactions are governed by quantum chromodynamics (QCD), the theory of strong interaction. In the early universe, these particles moved (nearly) freely in a quark-gluon plasma.
This is a joint press release of University Muenster and Heidelberg as well as the GSI Helmholtzzentrum für Schwerionenforschung in Darmstadt.
Then, in a phase transition, they combined and formed hadrons, among them the building blocks of atomic nuclei, protons and neutrons. In the current issue of...
Thin-film solar cells made of crystalline silicon are inexpensive and achieve efficiencies of a good 14 percent. However, they could do even better if their shiny surfaces reflected less light. A team led by Prof. Christiane Becker from the Helmholtz-Zentrum Berlin (HZB) has now patented a sophisticated new solution to this problem.
"It is not enough simply to bring more light into the cell," says Christiane Becker. Such surface structures can even ultimately reduce the efficiency by...
A study in the journal Bulletin of Marine Science describes a new, blood-red species of octocoral found in Panama. The species in the genus Thesea was discovered in the threatened low-light reef environment on Hannibal Bank, 60 kilometers off mainland Pacific Panama, by researchers at the Smithsonian Tropical Research Institute in Panama (STRI) and the Centro de Investigación en Ciencias del Mar y Limnología (CIMAR) at the University of Costa Rica.
Scientists established the new species, Thesea dalioi, by comparing its physical traits, such as branch thickness and the bright red colony color, with the...
Scientists have succeeded in observing the first long-distance transfer of information in a magnetic group of materials known as antiferromagnets.
An international team of researchers has mapped Nemo's genome, providing the research community with an invaluable resource to decode the response of fish to...
21.09.2018 | Event News
03.09.2018 | Event News
27.08.2018 | Event News
21.09.2018 | Physics and Astronomy
21.09.2018 | Life Sciences
21.09.2018 | Event News