A Swedish research group, partly financed by NWO, has discovered a new mechanism for cell division in a microorganism found in extremely hot and acidic conditions.
The results of the research offer insights into evolution, but also into the functioning of the human body. The research has been recently published in PNAS, the magazine of the American National Academy of Sciences. Thijs Ettema, member of the research group, received a Rubicon grant from NWO in 2006 to gain experience abroad.
The new mechanism for cell division was discovered in Sulfolobus acidocaldarius, a microorganism found in hot springs in Yellowstone National Park. The organism is a member of the third main group of life on earth, the Archaea. Archaea, like bacteria, are unicellular organisms but in terms of evolution they are more closely related to another main group of living things, the eukaryotes (humans, animals, plants, fungi, etc).
It is striking that these cell division proteins are not related to other proteins known to be involved in cell division. Some of the proteins in the new type of cell division are similar to proteins in other eukaryotes that have a completely different function. The study shows that the proteins involved in cell division in Sulfolobus acidocaldarius are related to the so-called ESCRT proteins. In eukaryotes, and therefore also in humans, these proteins are involved in protein transport within the cell. It has recently been shown that the HIV virus makes use of the ESCRT transport system to escape from the host cell. Studying the process of cell division in Sulfolobus acidocaldarius could therefore lead to new insights into the processes involving ESCRT proteins, such as HIV particle release.Evolution
Among other things, microbiologist Thijs Ettema has taken a closer look at the resemblance between the cell division proteins and the ESCRT proteins. Ettema carried out his research in Sweden at the University of Uppsala. Ettema obtained his doctorate from Wageningen University and Research Centre in 2005. He was awarded a Rubicon grant from NWO in 2006. Rubicon offers post-docs who have recently gained their doctorate the possibility of gaining experience at a centre of excellence abroad.Publication details:
A unique cell division machinery in the Archaea, PNAS, November 5, 2008
Kim van den Wijngaard | alfa
O2 stable hydrogenases for applications
23.07.2018 | Max-Planck-Institut für Chemische Energiekonversion
Scientists uncover the role of a protein in production & survival of myelin-forming cells
19.07.2018 | Advanced Science Research Center, GC/CUNY
A new manufacturing technique uses a process similar to newspaper printing to form smoother and more flexible metals for making ultrafast electronic devices.
The low-cost process, developed by Purdue University researchers, combines tools already used in industry for manufacturing metals on a large scale, but uses...
For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...
Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...
Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
13.07.2018 | Event News
12.07.2018 | Event News
03.07.2018 | Event News
23.07.2018 | Science Education
23.07.2018 | Health and Medicine
23.07.2018 | Life Sciences