Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Proteins in DNA damage response network targeted for new therapies, Moffitt researchers say

16.10.2012
Moffitt Cancer Center Researchers Find DNA Damage Response Network Integrates with Other Cell Activities, Opens Door to New Cancer Therapies
Researchers at Moffitt Cancer Center and colleagues at the University of South Florida; Duke University; Johns Hopkins University; the Brazilian National Cancer Institute; and the Rio de Janeiro Federal Institute of Education, Science and Technology have discovered that an intricate system to repair DNA damage called the “DNA damage response” (DDR) contains previously unknown components, including proteins that could be targeted as sensitizers for chemotherapy. Some of these targets may already have drugs available that have unrecognized uses in cancer therapy, said the researchers.

The study appears in the Sept. 18 issue of Science Signaling.

“A domain called BRCT is frequently present in proteins involved in the DDR network,” said study lead author Alvaro N.A. Monteiro, Ph.D., senior member of Moffitt’s Cancer Epidemiology Program. “We undertook a systematic analysis of the BRCT domain, a protein module that plays a critical role in the DDR, and found a large network of interacting proteins centered on BRCT-containing proteins. In doing so, we discovered new potential players in the DDR. These new players may constitute potential biomarkers for drug response or targets for treatment.”

According to the authors, their data could be used to build a more comprehensive map of the components and interactions involved in the DDR, a system through which proteins detect DNA damage, promote repair and coordinate the cell cycle.

Because defects in the DDR can lead to cancer, the properly functioning network is considered to be a barrier against tumor growth. Chemotherapy regimens exploit weaknesses in the system to kill cancer cells. The new discoveries augment knowledge about the DDR by adding information on the function of specific proteins involved with BRCT-containing proteins.

“Our expectation is that the establishment of the BRCT-network will help identify potential sensitizers of therapy and accelerate the development of new therapeutic strategies,” Monteiro said.

The research was supported in part by the U.S. Army Medical Research and Materiel Command, National Functional Genomics Center (W81XWH-08-2-0101), the Florida Breast Cancer Foundation, and the National Cancer Institute, part of the National Institutes of Health (P50-CA119997).

About Moffitt Cancer Center
Located in Tampa, Moffitt is one of only 41 National Cancer Institute-designated Comprehensive Cancer Centers, a distinction that recognizes Moffitt’s excellence in research, its contributions to clinical trials, prevention and cancer control. Since 1999, Moffitt has been listed in U.S. News & World Report as one of “America’s Best Hospitals” for cancer. With more than 4,200 employees, Moffitt has an economic impact on the state of nearly $2 billion. For more information, visit MOFFITT.org, and follow the Moffitt momentum on Facebook, twitter and YouTube.

Media release by Florida Science Communications

Kim Polacek | EurekAlert!
Further information:
http://www.moffitt.org

Further reports about: BRCT BRCT-containing Cancer DNA DNA damage Moffitt Cancer Center Protein proteins specific protein

More articles from Life Sciences:

nachricht In focus: Peptides, the “little brothers and sisters” of proteins
12.11.2018 | Technische Universität Berlin

nachricht How to produce fluorescent nanoparticles for medical applications in a nuclear reactor
09.11.2018 | Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Leap Into Quantum Technology

Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.

In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...

Im Focus: Research icebreaker Polarstern begins the Antarctic season

What does it look like below the ice shelf of the calved massive iceberg A68?

On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.

Im Focus: Penn engineers develop ultrathin, ultralight 'nanocardboard'

When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure

Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...

Im Focus: Coping with errors in the quantum age

Physicists at ETH Zurich demonstrate how errors that occur during the manipulation of quantum system can be monitored and corrected on the fly

The field of quantum computation has seen tremendous progress in recent years. Bit by bit, quantum devices start to challenge conventional computers, at least...

Im Focus: Nanorobots propel through the eye

Scientists developed specially coated nanometer-sized vehicles that can be actively moved through dense tissue like the vitreous of the eye. So far, the transport of nano-vehicles has only been demonstrated in model systems or biological fluids, but not in real tissue. The work was published in the journal Science Advances and constitutes one step further towards nanorobots becoming minimally-invasive tools for precisely delivering medicine to where it is needed.

Researchers of the “Micro, Nano and Molecular Systems” Lab at the Max Planck Institute for Intelligent Systems in Stuttgart, together with an international...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

“3rd Conference on Laser Polishing – LaP 2018” Attracts International Experts and Users

09.11.2018 | Event News

On the brain’s ability to find the right direction

06.11.2018 | Event News

European Space Talks: Weltraumschrott – eine Gefahr für die Gesellschaft?

23.10.2018 | Event News

 
Latest News

In focus: Peptides, the “little brothers and sisters” of proteins

12.11.2018 | Life Sciences

Materials scientist creates fabric alternative to batteries for wearable devices

12.11.2018 | Materials Sciences

A two-atom quantum duet

12.11.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>