The STK25 protein contributes to cell growth. Researchers at Sahlgrenska Academy, University of Gothenburg, Sweden, have discovered that the protein also affects metabolism, demonstrating that elevated levels accelerate the progress of diabetes in mice.
Researchers at Sahlgrenska Academy, University of Gothenburg have discovered a protein that may open the door to a new method of treating type 2 diabetes and other diseases caused by metabolic disorders.
Current methods not effective
Emmelie Cansby’s doctoral thesis has shown that the reduction of STK25 protein in cell cultures improves metabolism. The studies also found that mice that have elevated STK25 levels and are fed a high-fat diet are more likely to develop symptoms of diabetes.
”Current methods for treating diabetes are not effective enough,” Emmelie Cansby says. “Furthermore, they have various adverse effects, including hypoglycemia, weight gain, edema and gastrointestinal problems. New, supplementary drugs for type 2 diabetes are badly needed.”
Her thesis concludes that the STK25 protein offers the potential for an entirely new way of treating diabetes.
“Future treatment of diabetes and other metabolic disorders will hopefully include drugs that inhibit the action of STK25,” she says.
Emmelie Cansby will present her thesis, Regulation of metabolism and inflammation by two protein kinases – AMPK and STK25, on September 5.
Link to thesis: http://hdl.handle.net/2077/35938
Emmelie Cansby, Doctoral Student, Sahlgrenska Academy, University of Gothenburg
Supervisor Margit Mahlapuu, Associate Professor, +46 706 310109, email@example.com
Henrik Axlid | idw - Informationsdienst Wissenschaft
Seeing on the Quick: New Insights into Active Vision in the Brain
15.08.2018 | Eberhard Karls Universität Tübingen
New Approach to Treating Chronic Itch
15.08.2018 | Universität Zürich
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
Scientists have discovered that the electrical resistance of a copper-oxide compound depends on the magnetic field in a very unusual way -- a finding that could help direct the search for materials that can perfectly conduct electricity at room temperatur
What happens when really powerful magnets--capable of producing magnetic fields nearly two million times stronger than Earth's--are applied to materials that...
08.08.2018 | Event News
27.07.2018 | Event News
25.07.2018 | Event News
15.08.2018 | Physics and Astronomy
15.08.2018 | Earth Sciences
15.08.2018 | Physics and Astronomy