The protein, known as S100PBP, does this by suppressing a second protein called cathepsin Z. The research team has shown that cathepsin Z makes pancreatic cancer cells sticky, allowing them to spread to their surrounding environment. Prior to this study nothing was known about the function of S100PBP in the body or the role that cathepsin Z plays in pancreactic cancer.
The findings, funded by the UK charity, Pancreatic Cancer Research Fund (PCRF), are reported today (26 March 2012) in The American Journal of Pathology.
Lead researcher Dr Tatjana Crnogorac-Jurcevic of Barts Cancer Institute at Queen Mary said: "We believe these findings are significant. A greater understanding of the role these proteins play in the adhesion and spread of pancreatic cancer to other organs, which is almost always the case in this deadly cancer, could help us to develop novel preventive and therapeutic targets."
Pancreatic cancer has the worst five year survival rate of any common cancer – 3 per cent - and this figure has not improved in forty years. With no early diagnostic test available, and symptoms that are often mistaken for less serious conditions, the majority of sufferers are diagnosed too late for surgery - currently the only possible curative option.
The team found that the production of cathepsin Z is regulated by S100PBP. When large quantities of S100PBP are present, less cathepsin Z is produced by the cancer cells, limiting their spread. PhD student and co-author Kate Lines said that the team hopes to secure further funding to progress this line of research: "We're especially keen to find out exactly how S100PBP controls the levels of cathepsin Z, so we can try to prevent its increase in cancer cells".
"Pancreatic cancer is an extremely complex cancer, and these findings add to the growing bank of knowledge regarding the number and roles of proteins involved in its aggressive spread throughout the body. We hope that these newly discovered proteins may ultimately prove to be key in paving the way for new therapies that could make a real difference to patients' prognosis."
Further information from Clare Elsley, Campus PR, tel 0113 357 2100, mob 07767 685168, firstname.lastname@example.org
Queen Mary, University of London Press office, tel 020 7882 3004, email@example.com
Clare Elsley | EurekAlert!
The Secret of the Rock Drawings
24.05.2019 | Max-Planck-Institut für Chemie
Chemical juggling with three particles
24.05.2019 | Rheinische Friedrich-Wilhelms-Universität Bonn
A new assessment of NASA's record of global temperatures revealed that the agency's estimate of Earth's long-term temperature rise in recent decades is accurate to within less than a tenth of a degree Fahrenheit, providing confidence that past and future research is correctly capturing rising surface temperatures.
The most complete assessment ever of statistical uncertainty within the GISS Surface Temperature Analysis (GISTEMP) data product shows that the annual values...
Physicists at the University of Basel are able to show for the first time how a single electron looks in an artificial atom. A newly developed method enables them to show the probability of an electron being present in a space. This allows improved control of electron spins, which could serve as the smallest information unit in a future quantum computer. The experiments were published in Physical Review Letters and the related theory in Physical Review B.
The spin of an electron is a promising candidate for use as the smallest information unit (qubit) of a quantum computer. Controlling and switching this spin or...
Engineers at the University of Tokyo continually pioneer new ways to improve battery technology. Professor Atsuo Yamada and his team recently developed a...
With a quantum coprocessor in the cloud, physicists from Innsbruck, Austria, open the door to the simulation of previously unsolvable problems in chemistry, materials research or high-energy physics. The research groups led by Rainer Blatt and Peter Zoller report in the journal Nature how they simulated particle physics phenomena on 20 quantum bits and how the quantum simulator self-verified the result for the first time.
Many scientists are currently working on investigating how quantum advantage can be exploited on hardware already available today. Three years ago, physicists...
'Quantum technologies' utilise the unique phenomena of quantum superposition and entanglement to encode and process information, with potentially profound benefits to a wide range of information technologies from communications to sensing and computing.
However a major challenge in developing these technologies is that the quantum phenomena are very fragile, and only a handful of physical systems have been...
29.04.2019 | Event News
17.04.2019 | Event News
15.04.2019 | Event News
24.05.2019 | Physics and Astronomy
24.05.2019 | Medical Engineering
24.05.2019 | Life Sciences